卡瓦内酯
卡瓦内酯（英語：Kavalactone）是一类内酯，常见于卡瓦醉椒（Piper methysticum）的根[1]，以及艷山薑（Alpinia zerumbet）[2]等物种中。
化合物
[编辑]| 名称 | 化学结构 | 双键 | R1 | R2 | R3 | R4 |
|---|---|---|---|---|---|---|
| 甲氧醉椒素 | 
|
5(6), 7(8) | -OCH3 | -H | -H | -H |
| 10-methoxyyangonin | 5(6), 7(8) | -OCH3 | -H | -OCH3 | -H | |
| 11-methoxyyangonin | 5(6), 7(8) | -OCH3 | -OCH3 | -H | -H | |
| 11-hydroxyyangonin | 5(6), 7(8) | -OCH3 | -OH | -H | -H | |
| 去甲氧基醉椒素 | 
|
5(6), 7(8) | -H | -H | -H | -H |
| 11-methoxy-12-hydroxydehydrokavain | 5(6), 7(8) | -OH | -OCH3 | -H | -H | |
| 7,8-dihydroyangonin | 5(6) | -OCH3 | -H | -H | -H | |
| 醉椒素 | 
|
7(8) | -H | -H | -H | -H |
| 5-hydroxykavain | 7(8) | -H | -H | -H | -OH | |
| 5,6-dihydroyangonin | 7(8) | -OCH3 | -H | -H | -H | |
| 7,8-二氢醉椒素 | 
|
无 | -H | -H | -H | -H |
| 5,6,7,8-tetrahydroyangonin | 无 | -OCH3 | -H | -H | -H | |
| 5,6-dehydromethysticin | 5(6), 7(8) | -O-CH2-O- | -H | -H | ||
| 麻醉椒苦素 | 
|
7(8) | -O-CH2-O- | -H | -H | |
| 7,8-二氢麻醉椒苦素 | 
|
无 | -O-CH2-O- | -H | -H | |
参考文献
[编辑]参考文献
[编辑]- ^ Malani, Joji. Evaluation of the effects of Kava on the Liver (PDF). Fiji School of Medicine. 2002-12-03 [2009-09-04]. （原始内容 (PDF)存档于2009-03-20）.
- ^ Tadiparthi, Krishnaji; Anand, Pragya. A Review on Synthetic Approaches towards Kavalactones. Synthesis. 2021, 53 (19): 3469–3484. S2CID 236392304. doi:10.1055/s-0040-1706044.
外部链接
[编辑]- NIH Kava Chemistry & Toxicology, Executive Summary. [2025-01-02]. （原始内容存档于2025-03-05）.
- The great kava boom: how Fiji's beloved psychoactive brew is going global The Guardian, 2020