杨梅醇

Myricanol
识别信息
	IUPAC命名法 (9R)-16,17-dimethoxytricyclo[12.3.1.12,6]nonadeca-1(17),2,4,6(19),14(18),15-hexaene-3,9,15-triol; ;
CAS号	33606-81-4
PubChem CID	161779;
ChemSpider	142086;
ChEMBL	ChEMBL2152654;
CompTox Dashboard (EPA)	DTXSID10955239 ;
化学信息
化学式	C21H26O5
摩尔质量	358.43 g·mol−1
3D模型（JSmol）	交互式图像;
	SMILES COC1=C2C=C(CCCC[C@H](CCC3=CC2=C(C=C3)O)O)C(=C1OC)O;
	InChI InChI=1S/C21H26O5/c1-25-20-17-12-14(19(24)21(20)26-2)5-3-4-6-15(22)9-7-13-8-10-18(23)16(17)11-13/h8,10-12,15,22-24H,3-7,9H2,1-2H3/t15-/m1/s1; Key:SBGBAZQAEOWGFT-OAHLLOKOSA-N;

杨梅醇（化学式：C₂₁H₂₆O₅）是一种天然产物，可作为烟酰胺磷酸核糖转移酶（英语：Nicotinamide phosphoribosyltransferase）（NAMPT）^[1]和SIRT1等酶的激活剂。^[2]^[3]它来源于阿育吠陀药用植物Myrica nagi等物种，常与类似化合物（如杨梅素）共存。^[4]^[5]^[6]

参考文献

^ Lyu P, Li S, Han Y, Shen S, Feng Z, Hao P, Li Z, Lin L. Affinity-based protein profiling-driven discovery of myricanol as a Nampt activator. Bioorganic Chemistry. April 2023, 133. PMID 36841049. doi:10.1016/j.bioorg.2023.106435. 已忽略未知参数|article-number= (帮助)
^ Shen S, Liao Q, Liu J, Pan R, Lee SM, Lin L. Myricanol rescues dexamethasone-induced muscle dysfunction via a sirtuin 1-dependent mechanism. Journal of Cachexia, Sarcopenia and Muscle. April 2019, 10 (2): 429–444. PMC 6463464 . PMID 30793539. doi:10.1002/jcsm.12393.
^ Li T, Hu X, Fan L, Yang Y, He K. Myricanol improves metabolic profiles in dexamethasone induced lipid and protein metabolism disorders in mice. Biomedicine & Pharmacotherapy = Biomedecine & Pharmacotherapie. May 2024, 174. PMID 38583337. doi:10.1016/j.biopha.2024.116557. 已忽略未知参数|article-number= (帮助)
^ Ohta S, Sakurai N, Kamogawa A, Yaguchi Y, Inoue T, Shinoda M. [Protective effects of the bark of Myrica rubra Sieb. et Zucc. on experimental liver injuries]. Yakugaku Zasshi. April 1992, 112 (4): 244–252. PMID 1403657. doi:10.1248/yakushi1947.112.4_244.
^ Matsuda H, Morikawa T, Tao J, Ueda K, Yoshikawa M. Bioactive constituents of Chinese natural medicines. VII. Inhibitors of degranulation in RBL-2H3 cells and absolute stereostructures of three new diarylheptanoid glycosides from the bark of Myrica rubra. Chemical & Pharmaceutical Bulletin. February 2002, 50 (2): 208–215. PMID 11848211. doi:10.1248/cpb.50.208.
^ Bochicchio A, Schiavo L, Chiummiento L, Lupattelli P, Funicello M, Hanquet G, Choppin S, Colobert F. Convergent total synthesis of (±) myricanol, a cyclic natural diarylheptanoid. Organic & Biomolecular Chemistry. November 2018, 16 (45): 8859–8869. PMID 30411771. doi:10.1039/c8ob02052c.

延伸阅读

Shen S, Liao Q, Zhang T, Pan R, Lin L. Myricanol modulates skeletal muscle-adipose tissue crosstalk to alleviate high-fat diet-induced obesity and insulin resistance. British Journal of Pharmacology. October 2019, 176 (20): 3983–4001. PMC 6811775 . PMID 31339170. doi:10.1111/bph.14802.
Wu Y, Yang X, Zhang D, Lu C. Myricanol Inhibits the Type III Secretion System of Salmonella enterica Serovar Typhimurium by Interfering With the DNA-Binding Activity of HilD. Frontiers in Microbiology. 2020, 11. PMC 7546796 . PMID 33101243. doi:10.3389/fmicb.2020.571217 . 已忽略未知参数|article-number= (帮助)
Fan S, Wang C, Huang K, Liang M. Myricanol Inhibits Platelet Derived Growth Factor-BB-Induced Vascular Smooth Muscle Cells Proliferation and Migration in vitro and Intimal Hyperplasia in vivo by Targeting the Platelet-Derived Growth Factor Receptor-β and NF-κB Signaling. Frontiers in Physiology. 2021, 12. PMC 8850918 . PMID 35185599. doi:10.3389/fphys.2021.790345 . 已忽略未知参数|article-number= (帮助)
Shen S, Liao Q, Lyu P, Wang J, Lin L. Myricanol prevents aging-related sarcopenia by rescuing mitochondrial dysfunction via targeting peroxiredoxin 5. MedComm. June 2024, 5 (6). PMC 11167181 . PMID 38868327. doi:10.1002/mco2.566. 已忽略未知参数|article-number= (帮助)

[1] Lyu P, Li S, Han Y, Shen S, Feng Z, Hao P, Li Z, Lin L. Affinity-based protein profiling-driven discovery of myricanol as a Nampt activator. Bioorganic Chemistry. April 2023, 133. PMID 36841049. doi:10.1016/j.bioorg.2023.106435. 已忽略未知参数|article-number= (帮助)

[2] Shen S, Liao Q, Liu J, Pan R, Lee SM, Lin L. Myricanol rescues dexamethasone-induced muscle dysfunction via a sirtuin 1-dependent mechanism. Journal of Cachexia, Sarcopenia and Muscle. April 2019, 10 (2): 429–444. PMC 6463464 . PMID 30793539. doi:10.1002/jcsm.12393.

[3] Li T, Hu X, Fan L, Yang Y, He K. Myricanol improves metabolic profiles in dexamethasone induced lipid and protein metabolism disorders in mice. Biomedicine & Pharmacotherapy = Biomedecine & Pharmacotherapie. May 2024, 174. PMID 38583337. doi:10.1016/j.biopha.2024.116557. 已忽略未知参数|article-number= (帮助)

[Ohta_1992-4] Ohta S, Sakurai N, Kamogawa A, Yaguchi Y, Inoue T, Shinoda M. [Protective effects of the bark of Myrica rubra Sieb. et Zucc. on experimental liver injuries]. Yakugaku Zasshi. April 1992, 112 (4): 244–252. PMID 1403657. doi:10.1248/yakushi1947.112.4_244.

[5] Matsuda H, Morikawa T, Tao J, Ueda K, Yoshikawa M. Bioactive constituents of Chinese natural medicines. VII. Inhibitors of degranulation in RBL-2H3 cells and absolute stereostructures of three new diarylheptanoid glycosides from the bark of Myrica rubra. Chemical & Pharmaceutical Bulletin. February 2002, 50 (2): 208–215. PMID 11848211. doi:10.1248/cpb.50.208.

[6] Bochicchio A, Schiavo L, Chiummiento L, Lupattelli P, Funicello M, Hanquet G, Choppin S, Colobert F. Convergent total synthesis of (±) myricanol, a cyclic natural diarylheptanoid. Organic & Biomolecular Chemistry. November 2018, 16 (45): 8859–8869. PMID 30411771. doi:10.1039/c8ob02052c.

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