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砹化钠

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砹化钠
首选IUPAC名
Sodium astatide
识别
CAS号 15194-75-9  checkY
PubChem 176262708
SMILES
 
  • [Na+].[At-]
性质
化学式 AtNa
摩尔质量 232.99 g·mol−1
熔点 518 °C(791 K)
热力学
ΔfHm298K −257 kJ/mol(估算)[1]
相关物质
相关化学品 砹化氫
砹化镁
若非注明,所有数据均出自标准状态(25 ℃,100 kPa)下。

砹化钠(英語:Sodium astatide)是一种二元无机化合物,是形成的,化学式为NaAt[2][3]

合成

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砹化钠溶液的制备方法是:从制备砹的α射线靶中蒸馏出砹,将其溶解于碳酸氢钠溶液中,然后用维生素C还原At+和At3+离子[4]

用途

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砹化钠已被提议代替碘-131用于放射治疗[4][5]

参考来源

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  1. ^ Burgers, Peter C.; Zeneyedpour, Lona; Luider, Theo M.; Holmes, John L. Estimation of thermodynamic and physicochemical properties of the alkali astatides: On the bond strength of molecular astatine (At 2 ) and the hydration enthalpy of astatide (At − ). Journal of Mass Spectrometry. 2024, 59 (4). ISSN 1076-5174. PMID 38488842. doi:10.1002/jms.5010可免费查阅. 
  2. ^ Watabe, Tadashi; Hosono, Makoto; Kinuya, Seigo; Yamada, Takahiro; Yanagida, Sachiko; Namba, Masao; Nakamura, Yoshihide. Manual on the proper use of sodium astatide ([211At]NaAt) injections in clinical trials for targeted alpha therapy (1st edition). Annals of Nuclear Medicine. 2021-07, 35 (7): 753–766. ISSN 1864-6433. PMC 8197710可免费查阅. PMID 33978932. doi:10.1007/s12149-021-01619-2. 
  3. ^ Ball, Philip. An affinity for astatine. Chemistry World英语Chemistry World. 2020-03-17 [2023-06-16] (英语). 
  4. ^ 4.0 4.1 Y. Shirakami. Preparation of [211At]-labeled sodium astatide (NaAt) by reducing with ascorbic acid for the treatment of thyroid cancer (PDF). RIKEN Accel. Prog. Rep.: 171. [2023-06-16]. 
  5. ^ Breakthrough alpha-ray treatment of cancer without external radiation. EurekAlert!. [2023-06-16] (英语).