2CB7

2CB7
臨床資料
其他名稱	2C-B-5-hemiFLY-β7
藥物類別	Serotonin receptor modulator; Serotonin 5-HT2A receptor modulator
ATC碼	未分配;
识别信息
	IUPAC命名法 (5-bromo-7-methoxy-3-oxatricyclo[6.4.1.04,13]trideca-4,6,8(13)-trien-9-yl)methanamine; ;
PubChem CID	16086376;
ChemSpider	17245030;
化学信息
化学式	C14H18BrNO2
摩尔质量	312.21 g·mol−1
3D模型（JSmol）	交互式图像;
	SMILES COC1=CC(=C2C3=C1C(CCCC3CO2)CN)Br;
	InChI InChI=1S/C14H18BrNO2/c1-17-11-5-10(15)14-13-9(7-18-14)4-2-3-8(6-16)12(11)13/h5,8-9H,2-4,6-7,16H2,1H3; Key:IKKCIFAOANLPEY-UHFFFAOYSA-N;

2CB7，别名2C-B-5-hemiFLY-β7，是一种有机化合物，化学式为C
12H
16F
3NO
2S，它是苯乙胺、2C及苯并呋喃家族的血清素受体调节剂，具有syn-和anti-立体异构体，这些异构体也是(+)-和(−)-对映异构体的外消旋混合物。^[1]^[2]它最初于2006年被报道。^[3]^[4]^[1]

参考文献

^ ^1.0 ^1.1 McLean TH, Parrish JC, Braden MR, Marona-Lewicka D, Gallardo-Godoy A, Nichols DE. 1-Aminomethylbenzocycloalkanes: conformationally restricted hallucinogenic phenethylamine analogues as functionally selective 5-HT2A receptor agonists. Journal of Medicinal Chemistry. September 2006, 49 (19): 5794–5803. PMID 16970404. doi:10.1021/jm060656o.
^ Braden MR. Towards a biophysical understanding of hallucinogen action (Ph.D.论文). Purdue University. 2007. ProQuest 304838368. Table 4.7 Effect of the N6.55(343)A mutation on binding to the h5-HT2A receptor. [...] Table 4.8 Effect of the N6.55(343)A mutation on h5-HT2A receptor-mediated PI hydrolysis.
^ Trachsel D, Lehmann D, Enzensperger C. Phenethylamine: von der Struktur zur Funktion [Phenethylamines: From Structure to Function]. Nachtschatten-Science 1. Solothurn: Nachtschatten-Verlag. 2013: 848–849. ISBN 978-3-03788-700-4. OCLC 858805226. （原始内容存档于21 August 2025）（德语）.
^ Duan W, Cao D, Wang S, Cheng J. Serotonin 2A Receptor (5-HT_2AR) Agonists: Psychedelics and Non-Hallucinogenic Analogues as Emerging Antidepressants. Chemical Reviews. January 2024, 124 (1): 124–163. PMID 38033123. doi:10.1021/acs.chemrev.3c00375. Cyclopentyl or cycloheptyl compounds, for example, 133, 134, and 135 (Figure 12B), however, showed decreased binding affinity for 5-HT2AR.

外部链接

2CB7 - Isomer Design

[McLean_2006-1] 1.0 ^1.1 McLean TH, Parrish JC, Braden MR, Marona-Lewicka D, Gallardo-Godoy A, Nichols DE. 1-Aminomethylbenzocycloalkanes: conformationally restricted hallucinogenic phenethylamine analogues as functionally selective 5-HT2A receptor agonists. Journal of Medicinal Chemistry. September 2006, 49 (19): 5794–5803. PMID 16970404. doi:10.1021/jm060656o.

[Braden_2007-2] Braden MR. Towards a biophysical understanding of hallucinogen action (Ph.D.论文). Purdue University. 2007. ProQuest 304838368. Table 4.7 Effect of the N6.55(343)A mutation on binding to the h5-HT2A receptor. [...] Table 4.8 Effect of the N6.55(343)A mutation on h5-HT2A receptor-mediated PI hydrolysis.

[Trachsel_2013-3] Trachsel D, Lehmann D, Enzensperger C. Phenethylamine: von der Struktur zur Funktion [Phenethylamines: From Structure to Function]. Nachtschatten-Science 1. Solothurn: Nachtschatten-Verlag. 2013: 848–849. ISBN 978-3-03788-700-4. OCLC 858805226. （原始内容存档于21 August 2025）（德语）.

[Duan_2024-4] Duan W, Cao D, Wang S, Cheng J. Serotonin 2A Receptor (5-HT_2AR) Agonists: Psychedelics and Non-Hallucinogenic Analogues as Emerging Antidepressants. Chemical Reviews. January 2024, 124 (1): 124–163. PMID 38033123. doi:10.1021/acs.chemrev.3c00375. Cyclopentyl or cycloheptyl compounds, for example, 133, 134, and 135 (Figure 12B), however, showed decreased binding affinity for 5-HT2AR.

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