ACP-105

ACP-105
法律規範狀態
法律規範	美：Investigational new drug;
识别信息
	IUPAC命名法 2-chloro-4-(3-hydroxy-3-methyl-8-azabicyclo[3.2.1]octan-8-yl)-3-methylbenzonitrile; ;
CAS号	1048998-11-3
PubChem CID	11507567;
ChemSpider	9682364;
ChEMBL	ChEMBL3410856;
CompTox Dashboard (EPA)	DTXSID101134942 ;
化学信息
化学式	C16H19ClN2O
摩尔质量	290.79 g·mol−1
3D模型（JSmol）	交互式图像;
	SMILES CC1=C(C=CC(=C1Cl)C#N)N2C3CCC2CC(C3)(C)O;
	InChI InChI=1S/C16H19ClN2O/c1-10-14(6-3-11(9-18)15(10)17)19-12-4-5-13(19)8-16(2,20)7-12/h3,6,12-13,20H,4-5,7-8H2,1-2H3; Key:OUEODVPKPRQETQ-UHFFFAOYSA-N;

参考文献

^ Schlienger N, Lund BW, Pawlas J, Badalassi F, Bertozzi F, Lewinsky R, et al. Synthesis, structure-activity relationships, and characterization of novel nonsteroidal and selective androgen receptor modulators. Journal of Medicinal Chemistry. November 2009, 52 (22): 7186–7191. PMID 19856921. doi:10.1021/jm901149c.
^ Dayger C, Villasana L, Pfankuch T, Davis M, Raber J. Effects of the SARM ACP-105 on rotorod performance and cued fear conditioning in sham-irradiated and irradiated female mice. Brain Research. March 2011, 1381: 134–140. PMC 3048897 . PMID 21219889. doi:10.1016/j.brainres.2010.12.088.
^ George S, Petit GH, Gouras GK, Brundin P, Olsson R. Nonsteroidal selective androgen receptor modulators and selective estrogen receptor β agonists moderate cognitive deficits and amyloid-β levels in a mouse model of Alzheimer's disease. ACS Chemical Neuroscience. December 2013, 4 (12): 1537–1548. PMC 3867967 . PMID 24020966. doi:10.1021/cn400133s.
^ Cutler C, Viljanto M, Taylor P, Hincks P, Biddle S, Van Eenoo P. Identification of equine in vitro metabolites of seven non-steroidal selective androgen receptor modulators for doping control purposes. Drug Testing and Analysis. October 2021, 14 (2): 349–370. PMID 34714606. S2CID 240152623. doi:10.1002/dta.3189. hdl:1854/LU-8740373 .