AKAP11

AKAP11
識別號
别名	AKAP11；, AKAP-11, AKAP220, PPP1R44, PRKA11, A-kinase anchoring protein 11
外部ID	OMIM：604696 MGI：2684060 HomoloGene：8279 GeneCards：AKAP11
基因位置（人类）
染色体	13號染色體
终止	42,323,261 bp
基因位置（小鼠）
染色体	小鼠14号染色体
终止	78,774,248 bp
RNA表达模式
	; ;
	查阅更多表达数据
基因本體
分子功能	• protein phosphatase 1 binding; • protein kinase A binding; • 血浆蛋白结合;
細胞組分	• 細胞質; • 过氧化物酶体; • 细胞骨架; • 微管组织中心; • 核仁; • 细胞质基质; • 细胞膜;
生物學過程	• intracellular signal transduction; • regulation of protein kinase A signaling; • protein localization;
	Sources:Amigo / QuickGO
直系同源
	11215
	219181
	ENSG00000023516
	ENSMUSG00000022016
	Q9UKA4
	无数据
	NM_016248; NM_144490
	NM_001164503; NM_001346784
	NP_057332
	无数据
	維基數據
檢視/編輯人類	檢視/編輯小鼠

人类A-激酶锚定蛋白11是AKAP11基因编码的蛋白。

A-激酶锚定蛋白（AKAP）是一类结构多样的蛋白质，它们的共同功能是与蛋白激酶A（PKA）的调节亚基结合，并将全酶限制在细胞内的特定位置。该基因编码AKAP家族的一个成员。编码蛋白在精子发生过程中以及成熟精子中高表达。它在睾丸中与PKA的RI和RII亚基结合。除了在精子发生和精子功能中可能发挥的作用外，它还可能参与体细胞和生殖细胞的细胞周期调控。

相互作用

有研究表明AKAP11与下列蛋白有相互作用：

GSK3B；
PPP1CA；^[5]^[6]
PRKAR2A；
PRKAR2B；^[7]
VAPB。^[8] 与AKAP3类似，AKAP11通过其氨基端与FFAT基序结合。^[9]

在躁郁症中的作用

基于对13933位躁郁症病人和14422位对照正常人的全外显子研究，AKAP11已被确认是雙相障礙确定危险基因。 ^[10]

^ ^1.0 ^1.1 ^1.2 GRCh38: Ensembl release 89: ENSG00000023516 - Ensembl, May 2017
^ ^2.0 ^2.1 ^2.2 GRCm38: Ensembl release 89: ENSMUSG00000022016 - Ensembl, May 2017
^ Human PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Mouse PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Tanji C, Yamamoto H, Yorioka N, Kohno N, Kikuchi K, Kikuchi A. A-kinase anchoring protein AKAP220 binds to glycogen synthase kinase-3beta (GSK-3beta ) and mediates protein kinase A-dependent inhibition of GSK-3beta. J. Biol. Chem. October 2002, 277 (40): 36955–61. PMID 12147701. doi:10.1074/jbc.M206210200 .
^ Schillace RV, Scott JD. Association of the type 1 protein phosphatase PP1 with the A-kinase anchoring protein AKAP220. Curr. Biol. March 1999, 9 (6): 321–4. Bibcode:1999CBio....9..321S. PMID 10209101. doi:10.1016/S0960-9822(99)80141-9 .
^ Reinton N, Collas P, Haugen TB, Skâlhegg BS, Hansson V, Jahnsen T, Taskén K. Localization of a novel human A-kinase-anchoring protein, hAKAP220, during spermatogenesis. Dev. Biol. July 2000, 223 (1): 194–204. PMID 10864471. doi:10.1006/dbio.2000.9725 .
^ Huttlin EL, Ting L, Bruckner RJ, Gebreab F, Gygi MP, Szpyt J, et al. The BioPlex Network: A Systematic Exploration of the Human Interactome. Cell. 2015, 162 (2): 425–40. PMC 4617211 . PMID 26186194. doi:10.1016/j.cell.2015.06.043.
^ Mikitova V, Levine TP. Analysis of the key elements of FFAT-like motifs identifies new proteins that potentially bind VAP on the ER, including two AKAPs and FAPP2.. PLOS ONE. 2012, 7 (1). Bibcode:2012PLoSO...730455M. PMC 3261905 . PMID 22276202. doi:10.1371/journal.pone.0030455 . 已忽略未知参数|article-number= (帮助)
^ Palmer DS, Howrigan DP, Chapman SB, Adolfsson R, Bass N, Blackwood D, Boks MP, Chen CY, Churchhouse C, Corvin AP, Craddock N, Curtis D, Di Florio A, Dickerson F, Freimer NB, Goes FS, Jia X, Jones I, Jones L, Jonsson L, Kahn RS, Landén M, Locke AE, McIntosh AM, McQuillin A, Morris DW, O'Donovan MC, Ophoff RA, Owen MJ, Pedersen NL, Posthuma D, Reif A, Risch N, Schaefer C, Scott L, Singh T, Smoller JW, Solomonson M, St Clair D, Stahl EA, Vreeker A, Walters JT, Wang W, Watts A, Yolken R, Zandi PP, Neale BM. Exome sequencing in bipolar disorder identifies AKAP11 as a risk gene shared with schizophrenia. Nature Genetics. 2022, 54: 541––547.

[refGRCh38Ensembl-1] 1.0 ^1.1 ^1.2 GRCh38: Ensembl release 89: ENSG00000023516 - Ensembl, May 2017

[refGRCm38Ensembl-2] 2.0 ^2.1 ^2.2 GRCm38: Ensembl release 89: ENSMUSG00000022016 - Ensembl, May 2017

[3] Human PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] Mouse PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid12147701-5] Tanji C, Yamamoto H, Yorioka N, Kohno N, Kikuchi K, Kikuchi A. A-kinase anchoring protein AKAP220 binds to glycogen synthase kinase-3beta (GSK-3beta ) and mediates protein kinase A-dependent inhibition of GSK-3beta. J. Biol. Chem. October 2002, 277 (40): 36955–61. PMID 12147701. doi:10.1074/jbc.M206210200 .

[pmid10209101-6] Schillace RV, Scott JD. Association of the type 1 protein phosphatase PP1 with the A-kinase anchoring protein AKAP220. Curr. Biol. March 1999, 9 (6): 321–4. Bibcode:1999CBio....9..321S. PMID 10209101. doi:10.1016/S0960-9822(99)80141-9 .

[pmid10864471-7] Reinton N, Collas P, Haugen TB, Skâlhegg BS, Hansson V, Jahnsen T, Taskén K. Localization of a novel human A-kinase-anchoring protein, hAKAP220, during spermatogenesis. Dev. Biol. July 2000, 223 (1): 194–204. PMID 10864471. doi:10.1006/dbio.2000.9725 .

[pmid26186194-8] Huttlin EL, Ting L, Bruckner RJ, Gebreab F, Gygi MP, Szpyt J, et al. The BioPlex Network: A Systematic Exploration of the Human Interactome. Cell. 2015, 162 (2): 425–40. PMC 4617211 . PMID 26186194. doi:10.1016/j.cell.2015.06.043.

[pmid22276202-9] Mikitova V, Levine TP. Analysis of the key elements of FFAT-like motifs identifies new proteins that potentially bind VAP on the ER, including two AKAPs and FAPP2.. PLOS ONE. 2012, 7 (1). Bibcode:2012PLoSO...730455M. PMC 3261905 . PMID 22276202. doi:10.1371/journal.pone.0030455 . 已忽略未知参数|article-number= (帮助)

[palmer2022-10] Palmer DS, Howrigan DP, Chapman SB, Adolfsson R, Bass N, Blackwood D, Boks MP, Chen CY, Churchhouse C, Corvin AP, Craddock N, Curtis D, Di Florio A, Dickerson F, Freimer NB, Goes FS, Jia X, Jones I, Jones L, Jonsson L, Kahn RS, Landén M, Locke AE, McIntosh AM, McQuillin A, Morris DW, O'Donovan MC, Ophoff RA, Owen MJ, Pedersen NL, Posthuma D, Reif A, Risch N, Schaefer C, Scott L, Singh T, Smoller JW, Solomonson M, St Clair D, Stahl EA, Vreeker A, Walters JT, Wang W, Watts A, Yolken R, Zandi PP, Neale BM. Exome sequencing in bipolar disorder identifies AKAP11 as a risk gene shared with schizophrenia. Nature Genetics. 2022, 54: 541––547.

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