B4GALT5

B4GALT5
識別號
别名	B4GALT5；, B4Gal-T5, BETA4-GALT-IV, beta4Gal-T5, beta4GalT-V, gt-V, beta-1,4-galactosyltransferase 5
外部ID	OMIM：604016 MGI：1927169 HomoloGene：3507 GeneCards：B4GALT5
基因位置（人类）
染色体	20號染色體
终止	49,713,878 bp
基因位置（小鼠）
染色体	小鼠2号染色体
终止	167,191,103 bp
RNA表达模式
	; ;
	查阅更多表达数据
基因本體
分子功能	• glycosyltransferase activity; • 轉移酶活性; • galactosyltransferase activity; • 金屬離子結合; • beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase activity; • N-acetyllactosamine synthase activity; • UDP-galactose:glucosylceramide beta-1,4-galactosyltransferase activity;
細胞組分	• integral component of membrane; • Golgi cisterna membrane; • Golgi membrane; • 高尔基体; • 膜;
生物學過程	• 蛋白质糖基化; • keratan sulfate biosynthetic process; • O-glycan processing; • 碳水化合物代謝; • poly-N-acetyllactosamine biosynthetic process; • ganglioside biosynthetic process via lactosylceramide; • central nervous system neuron axonogenesis; • central nervous system myelination; • regulation of protein stability; • positive regulation of embryonic development; • neuron maturation; • 脂質代謝; • sphingolipid metabolic process;
	Sources:Amigo / QuickGO
直系同源
	9334
	56336
	ENSG00000158470
	ENSMUSG00000017929
	O43286
	Q9JMK0
	NM_004776
	NM_019835
	NP_004767
	NP_062809
	維基數據
檢視/編輯人類	檢視/編輯小鼠

β-1,4-半乳糖基转移酶5（英語：Beta-1,4-galactosyltransferase 5）是一种由人类基因B4GALT5 所表达的酶^[5]^[6]^[7]。

参考文献

^ ^1.0 ^1.1 ^1.2 GRCh38: Ensembl release 89: ENSG00000158470 - Ensembl, May 2017
^ ^2.0 ^2.1 ^2.2 GRCm38: Ensembl release 89: ENSMUSG00000017929 - Ensembl, May 2017
^ Human PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Mouse PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Lo NW, Shaper JH, Pevsner J, Shaper NL. The expanding beta 4-galactosyltransferase gene family: messages from the databanks. Glycobiology. Aug 1998, 8 (5): 517–26. PMID 9597550. doi:10.1093/glycob/8.5.517.
^ Sato T, Furukawa K, Bakker H, Van den Eijnden DH, Van Die I. Molecular cloning of a human cDNA encoding β-1,4-galactosyltransferase with 37% identity to mammalian UDP-Gal:GlcNAc β-1,4-galactosyltransferase. Proc Natl Acad Sci U S A. Feb 1998, 95 (2): 472–7. PMC 18444 . PMID 9435216. doi:10.1073/pnas.95.2.472.
^ Entrez Gene: B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5.

延伸阅读

Amado M, Almeida R, Schwientek T, Clausen H. Identification and characterization of large galactosyltransferase gene families: galactosyltransferases for all functions. Biochim. Biophys. Acta. 2000, 1473 (1): 35–53. PMID 10580128. doi:10.1016/S0304-4165(99)00168-3.
Sato T, Aoki N, Matsuda T, Furukawa K. Differential effect of alpha-lactalbumin on beta-1,4-galactosyltransferase IV activities. Biochem. Biophys. Res. Commun. 1998, 244 (3): 637–41. PMID 9535717. doi:10.1006/bbrc.1998.8327.
Deloukas P, Matthews LH, Ashurst J; et al. The DNA sequence and comparative analysis of human chromosome 20. Nature. 2002, 414 (6866): 865–71. PMID 11780052. doi:10.1038/414865a.
Jia L, Young MF, Powell J; et al. Gene expression profile of human bone marrow stromal cells: high-throughput expressed sequence tag sequencing analysis. Genomics. 2002, 79 (1): 7–17. PMID 11827452. doi:10.1006/geno.2001.6683.
Xu S, Zhang S, Chen C; et al. Over-expression of beta-1,4-galactosyltransferase V increases the growth of astrocytoma cell line. J. Exp. Clin. Cancer Res. 2003, 21 (3): 409–14. PMID 12385586.
Strausberg RL, Feingold EA, Grouse LH; et al. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proc. Natl. Acad. Sci. U.S.A. 2003, 99 (26): 16899–903. PMC 139241 . PMID 12477932. doi:10.1073/pnas.242603899.
Ota T, Suzuki Y, Nishikawa T; et al. Complete sequencing and characterization of 21,243 full-length human cDNAs. Nat. Genet. 2004, 36 (1): 40–5. PMID 14702039. doi:10.1038/ng1285.
Sato T, Furukawa K. Transcriptional regulation of the human beta-1,4-galactosyltransferase V gene in cancer cells: essential role of transcription factor Sp1. J. Biol. Chem. 2004, 279 (38): 39574–83. PMID 15263012. doi:10.1074/jbc.M405805200.
Gerhard DS, Wagner L, Feingold EA; et al. The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC). Genome Res. 2004, 14 (10B): 2121–7. PMC 528928 . PMID 15489334. doi:10.1101/gr.2596504.
Jiang J, Chen X, Shen J; et al. Beta1,4-galactosyltransferase V functions as a positive growth regulator in glioma. J. Biol. Chem. 2006, 281 (14): 9482–9. PMID 16461357. doi:10.1074/jbc.M504489200.
Sato T, Furukawa K. Sequential action of Ets-1 and Sp1 in the activation of the human beta-1,4-galactosyltransferase V gene involved in abnormal glycosylation characteristic of cancer cells. J. Biol. Chem. 2007, 282 (38): 27702–12. PMID 17656364. doi:10.1074/jbc.M611862200.
Kitayama K, Hayashida Y, Nishida K, Akama TO. Enzymes responsible for synthesis of corneal keratan sulfate glycosaminoglycans. J. Biol. Chem. 2007, 282 (41): 30085–96. PMID 17690104. doi:10.1074/jbc.M703695200.

[refGRCh38Ensembl-1] 1.0 ^1.1 ^1.2 GRCh38: Ensembl release 89: ENSG00000158470 - Ensembl, May 2017

[refGRCm38Ensembl-2] 2.0 ^2.1 ^2.2 GRCm38: Ensembl release 89: ENSMUSG00000017929 - Ensembl, May 2017

[3] Human PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] Mouse PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9597550-5] Lo NW, Shaper JH, Pevsner J, Shaper NL. The expanding beta 4-galactosyltransferase gene family: messages from the databanks. Glycobiology. Aug 1998, 8 (5): 517–26. PMID 9597550. doi:10.1093/glycob/8.5.517.

[pmid9435216-6] Sato T, Furukawa K, Bakker H, Van den Eijnden DH, Van Die I. Molecular cloning of a human cDNA encoding β-1,4-galactosyltransferase with 37% identity to mammalian UDP-Gal:GlcNAc β-1,4-galactosyltransferase. Proc Natl Acad Sci U S A. Feb 1998, 95 (2): 472–7. PMC 18444 . PMID 9435216. doi:10.1073/pnas.95.2.472.

[entrez-7] Entrez Gene: B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5.

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