HMOX1

HMOX1
已知的結構 PDB 直系同源搜索: PDBe RCSB PDBID列表 1N3U、​1N45、​1NI6、​1OYK、​1OYL、​1OZE、​1OZL、​1OZR、​1OZW、​1S13、​1S8C、​1T5P、​1TWN、​1TWR、​1XJZ、​1XK0、​1XK1、​1XK2、​1XK3、​3CZY、​3HOK、​3K4F、​3TGM、​4WD4、​5BTQ
識別號
别名	HMOX1；, HMOX1D, HO-1, HSP32, bK286B10, heme oxygenase 1
外部ID	OMIM：141250 MGI：96163 HomoloGene：31075 GeneCards：HMOX1
相關疾病
肥胖症
為以下藥物的標靶
Viroporin 3a
基因位置（人类） 染色体 22號染色體 基因座 22q12.3 起始 35,380,361 bp 终止 35,394,214 bp
基因位置（小鼠） 染色体 小鼠8号染色体 基因座 8 35.59 cM|8 C1 起始 75,820,249 bp 终止 75,827,217 bp
RNA表达模式
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基因本體 分子功能 • phospholipase D activity • protein homodimerization activity • heme oxygenase (decyclizing) activity • 金屬離子結合 • signal transducer activity • heme binding • 血浆蛋白结合 • 酶结合 • oxidoreductase activity 細胞組分 • 细胞质基质 • endoplasmic reticulum membrane • 膜 • 細胞內膜結合細胞器 • 核仁 • 内质网 • caveola • 细胞质的核周区域 • 细胞核 • 細胞外空間 生物學過程 • negative regulation of neuron apoptotic process • 细胞凋亡 • cellular iron ion homeostasis • 平滑肌細胞增殖的負調控 • cellular response to heat • intracellular signal transduction • negative regulation of mast cell cytokine production • response to hypoxia • 排泄作用 • low-density lipoprotein particle clearance • regulation of transcription from RNA polymerase II promoter in response to oxidative stress • small GTPase mediated signal transduction • negative regulation of DNA binding • response to nicotine • iron ion homeostasis • 细胞死亡 • heme oxidation • negative regulation of mast cell degranulation • cellular response to cadmium ion • regulation of angiogenesis • negative regulation of muscle cell apoptotic process • response to oxidative stress • negative regulation of DNA-binding transcription factor activity • cellular response to nutrient • positive regulation of angiogenesis • response to estrogen • wound healing involved in inflammatory response • 血压调节 • heme catabolic process • erythrocyte homeostasis • regulation of DNA-binding transcription factor activity • cellular response to arsenic-containing substance • 死亡域受体对外源性凋亡信号通路的负调控 • 血管新生 • intrinsic apoptotic signaling pathway in response to DNA damage • endothelial cell proliferation • positive regulation of I-kappaB kinase/NF-kappaB signaling • smooth muscle hyperplasia • protein homooligomerization • negative regulation of leukocyte migration • cellular response to hypoxia • response to hydrogen peroxide • negative regulation of cell population proliferation • heme metabolic process • positive regulation of smooth muscle cell proliferation • regulation of transcription from RNA polymerase II promoter in response to iron • positive regulation of apoptotic process • cellular response to cisplatin • positive regulation of macroautophagy • negative regulation of vascular associated smooth muscle cell proliferation • negative regulation of epithelial cell apoptotic process • liver regeneration • negative regulation of macroautophagy Sources:Amigo / QuickGO
直系同源
物種	人類	小鼠
Entrez	3162	15368
Ensembl	ENSG00000100292	ENSMUSG00000005413
UniProt	P09601	P14901
mRNA​序列	NM_002133	NM_010442
蛋白序列	NP_002124	NP_034572
基因位置​（UCSC）	Chr 22: 35.38 – 35.39 Mb	Chr 8: 75.82 – 75.83 Mb
PubMed​查找
維基數據
檢視/編輯人類 檢視/編輯小鼠

血红素加氧酶1（英語：heme oxygenase 1，缩写HMOX1或HO-1）是一种血红素加氧酶（EC 1.14.99.3），化学式为：C₁₄₇₅H₂₃₂₃O₄₂₇N₄₀₅S₈是血红素代谢过程中的重要酶，它将血红素转化为胆绿素。

另见

• HMOX2

延伸阅读

• Yachie A, Niida Y, Wada T, Igarashi N, Kaneda H, Toma T, Ohta K, Kasahara Y, Koizumi S. Oxidative stress causes enhanced endothelial cell injury in human heme oxygenase-1 deficiency. J Clin Invest. 1999, 103 (1): 129–35. PMC 407858 . PMID 9884342. doi:10.1172/JCI4165. 
• Wang J, Doré S. Heme oxygenase-1 exacerbates early brain injury after intracerebral haemorrhage.. Brain. 2007, 130 (6): 1643–52. PMC 2291147 . PMID 17525142. doi:10.1093/brain/awm095. 
• Soares MP, Brouard S, Smith RN, Bach FH. Heme oxygenase-1, a protective gene that prevents the rejection of transplanted organs. Immunol. Rev. 2002, 184: 275–85. PMID 12086318. doi:10.1034/j.1600-065x.2001.1840124.x. 
• Morse D, Choi AM. Heme oxygenase-1: the "emerging molecule" has arrived. Am. J. Respir. Cell Mol. Biol. 2002, 27 (1): 8–16. PMID 12091240. doi:10.1165/ajrcmb.27.1.4862. 
• Buelow R, Tullius SG, Volk HD. Protection of grafts by hemoxygenase-1 and its toxic product carbon monoxide. Am. J. Transplant. 2002, 1 (4): 313–5. PMID 12099373. doi:10.1034/j.1600-6143.2001.10404.x. 
• Ishikawa K. Heme oxygenase-1 against vascular insufficiency: roles of atherosclerotic disorders. Curr. Pharm. Des. 2003, 9 (30): 2489–97. PMID 14529548. doi:10.2174/1381612033453767. 
• Exner M, Minar E, Wagner O, Schillinger M. The role of heme oxygenase-1 promoter polymorphisms in human disease. Free Radic. Biol. Med. 2005, 37 (8): 1097–104. PMID 15451051. doi:10.1016/j.freeradbiomed.2004.07.008. 
• Ozono R. New biotechnological methods to reduce oxidative stress in the cardiovascular system: focusing on the Bach1/heme oxygenase-1 pathway. Current pharmaceutical biotechnology. 2006, 7 (2): 87–93. PMID 16724942. doi:10.2174/138920106776597630. 
• Tracz MJ, Alam J, Nath KA. Physiology and pathophysiology of heme: implications for kidney disease. J. Am. Soc. Nephrol. 2007, 18 (2): 414–20. PMID 17229906. doi:10.1681/ASN.2006080894. 
• Hill-Kapturczak N, Agarwal A. Haem oxygenase-1--a culprit in vascular and renal damage?. Nephrol. Dial. Transplant. 2007, 22 (6): 1495–9. PMID 17389623. doi:10.1093/ndt/gfm093.