LY-272015
外观
| 臨床資料 | |
|---|---|
| 其他名稱 | LY-272,015; 1-[(3,4-Dimethoxyphenyl)methy]-2,3,4,9-tetrahydro-6-methyl-1H-pyrido[3,4-b]indole |
| 识别信息 | |
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| CAS号 | 172895-15-7 |
| PubChem CID | |
| ChemSpider | |
| UNII | |
| CompTox Dashboard (EPA) | |
| 化学信息 | |
| 化学式 | C21H24N2O2 |
| 摩尔质量 | 336.44 g·mol−1 |
| 3D模型(JSmol) | |
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LY-272015是一种有机化合物,化学式为C21H24N2O2,属于β-咔啉衍生物,能作为血清素受体5-HT2B的拮抗剂,由礼来公司作为高血壓药物研发[1][2]。
参考文献
[编辑]- ^ Watts SW, Fink GD. 5-HT2B-receptor antagonist LY-272015 is antihypertensive in DOCA-salt-hypertensive rats. The American Journal of Physiology. March 1999, 276 (3): H944–52. PMID 10070078. S2CID 13301249. doi:10.1152/ajpheart.1999.276.3.H944.
- ^ Russell A, Banes A, Berlin H, Fink GD, Watts SW. 5-Hydroxytryptamine(2B) receptor function is enhanced in the N(omega)-nitro-L-arginine hypertensive rat. The Journal of Pharmacology and Experimental Therapeutics. October 2002, 303 (1): 179–87. PMID 12235249. S2CID 98055109. doi:10.1124/jpet.102.037390.