PHCCC

PHCCC
识别信息
	IUPAC命名法 (−)-N-Phenyl-7-(hydroxyimino)cyclopropa[b]chromen-1a-carboxamide; ;
CAS号	179068-02-1
PubChem CID	3579925;
ChemSpider	2816644;
化学信息
化学式	C17H14N2O3
摩尔质量	294.31 g·mol−1
3D模型（JSmol）	交互式图像;
	SMILES c4ccccc4NC(=O)C1(CC1C2=NO)Oc3ccccc23;
	InChI InChI=1S/C17H14N2O3/c20-16(18-11-6-2-1-3-7-11)17-10-13(17)15(19-21)12-8-4-5-9-14(12)22-17/h1-9,13,21H,10H2,(H,18,20); Key:FPXPIEZPAXSELW-UHFFFAOYSA-N;

PHCCC是一种作为谷氨酸受体（英语：glutamate receptor）配体的研究药物，可以作为mGluR₄（英语：Metabotropic glutamate receptor 4）的正向变构调节剂^[1]和mGluR₆的激动剂。^[2]动物研究表明，它具有抗焦虑作用。^[3]它和类似药物被提议用于治疗帕金森病。^[4]

参考文献

^ Maj M, Bruno V, Dragic Z, Yamamoto R, Battaglia G, Inderbitzin W, Stoehr N, Stein T, Gasparini F, Vranesic I, Kuhn R, Nicoletti F, Flor PJ. (−)-PHCCC, a positive allosteric modulator of mGluR4: characterization, mechanism of action, and neuroprotection. Neuropharmacology. December 2003, 45 (7): 895–906. PMID 14573382. S2CID 17446511. doi:10.1016/S0028-3908(03)00271-5.
^ Beqollari D, Kammermeier PJ. The mGlu(4) receptor allosteric modulator N-phenyl-7-(hydroxyimino)cyclopropa[b]chromen-1a-carboxamide acts as a direct agonist at mGlu(6) receptors. European Journal of Pharmacology. July 2008, 589 (1–3): 49–52. PMID 18593581. doi:10.1016/j.ejphar.2008.06.054.
^ Stachowicz K, Kłak K, Kłodzińska A, Chojnacka-Wojcik E, Pilc A. Anxiolytic-like effects of PHCCC, an allosteric modulator of mGlu4 receptors, in rats. European Journal of Pharmacology. September 2004, 498 (1–3): 153–6. PMID 15363989. doi:10.1016/j.ejphar.2004.07.001.
^ Niswender CM, Johnson KA, Weaver CD, Jones CK, Xiang Z, Luo Q, Rodriguez AL, Marlo JE, de Paulis T, Thompson AD, Days EL, Nalywajko T, Austin CA, Williams MB, Ayala JE, Williams R, Lindsley CW, Conn PJ. Discovery, characterization, and antiparkinsonian effect of novel positive allosteric modulators of metabotropic glutamate receptor 4. Molecular Pharmacology. November 2008, 74 (5): 1345–58. PMC 2574552 . PMID 18664603. doi:10.1124/mol.108.049551.

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