TRAF1

TRAF1
已知的結構
PDB	直系同源搜索: PDBe RCSB
PDBID列表
	3M0D
識別號
别名	TRAF1；, EBI6, MGC:10353, TNF receptor associated factor 1
外部ID	OMIM：601711 MGI：101836 HomoloGene：4138 GeneCards：TRAF1
基因位置（人类）
染色体	9號染色體
终止	120,929,173 bp
基因位置（小鼠）
染色体	小鼠2号染色体
终止	34,851,784 bp
RNA表达模式
	查阅更多表达数据
基因本體
分子功能	• thioesterase binding; • 鋅離子結合; • 血浆蛋白结合; • 泛素蛋白连接酶结合; • 相同蛋白质结合; • tumor necrosis factor receptor binding;
細胞組分	• 細胞質; • 细胞质基质; • 大分子复合体;
生物學過程	• regulation of apoptotic process; • 肿瘤坏死因子介导的信号通路的调控; • regulation of extrinsic apoptotic signaling pathway; • 訊息傳遞; • 细胞凋亡; • positive regulation of NF-kappaB transcription factor activity; • protein-containing complex assembly;
	Sources:Amigo / QuickGO
直系同源
	7185
	22029
	ENSG00000056558
	ENSMUSG00000026875
	Q13077
	P39428
	NM_005658; NM_001190945; NM_001190947
	NM_009421; NM_001326601
	NP_001177874; NP_001177876; NP_005649
	NP_001313530; NP_033447
	維基數據
檢視/編輯人類	檢視/編輯小鼠

TRAF1是人类基因 TRAF1 编码的蛋白质，属于一种TNF受体相关因子（TRAF）^[5]。

蛋白质的相互作用

TRAF1蛋白与下列蛋白質进行互作：

参考文献

^ ^1.0 ^1.1 ^1.2 GRCh38: Ensembl release 89: ENSG00000056558 - Ensembl, May 2017
^ ^2.0 ^2.1 ^2.2 GRCm38: Ensembl release 89: ENSMUSG00000026875 - Ensembl, May 2017
^ Human PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Mouse PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Rothe M, Wong SC, Henzel WJ, Goeddel DV. A novel family of putative signal transducers associated with the cytoplasmic domain of the 75 kDa tumor necrosis factor receptor. Cell. September 1994, 78 (4): 681–92. PMID 8069916. S2CID 28055231. doi:10.1016/0092-8674(94)90532-0.
^ ^6.0 ^6.1 Roy N, Deveraux QL, Takahashi R, Salvesen GS, Reed JC. The c-IAP-1 and c-IAP-2 proteins are direct inhibitors of specific caspases. EMBO J. Dec 1997, 16 (23): 6914–25. PMC 1170295 . PMID 9384571. doi:10.1093/emboj/16.23.6914.
^ ^7.0 ^7.1 Li X, Yang Y, Ashwell JD. TNF-RII and c-IAP1 mediate ubiquitination and degradation of TRAF2. Nature. March 2002, 416 (6878): 345–7. Bibcode:2002Natur.416..345L. PMID 11907583. S2CID 4325926. doi:10.1038/416345a.
^ Shu HB, Takeuchi M, Goeddel DV. The tumor necrosis factor receptor 2 signal transducers TRAF2 and c-IAP1 are components of the tumor necrosis factor receptor 1 signaling complex. Proc. Natl. Acad. Sci. U.S.A. November 1996, 93 (24): 13973–8. Bibcode:1996PNAS...9313973S. PMC 19479 . PMID 8943045. doi:10.1073/pnas.93.24.13973 .
^ Shu HB, Halpin DR, Goeddel DV. Casper is a FADD- and caspase-related inducer of apoptosis. Immunity. June 1997, 6 (6): 751–63. PMID 9208847. doi:10.1016/s1074-7613(00)80450-1 .
^ Kataoka T, Budd RC, Holler N, Thome M, Martinon F, Irmler M, Burns K, Hahne M, Kennedy N, Kovacsovics M, Tschopp J. The caspase-8 inhibitor FLIP promotes activation of NF-kappaB and Erk signaling pathways. Curr. Biol. June 2000, 10 (11): 640–8. PMID 10837247. S2CID 14819939. doi:10.1016/s0960-9822(00)00512-1 .
^ Micheau O, Tschopp J. Induction of TNF receptor I-mediated apoptosis via two sequential signaling complexes (PDF). Cell. July 2003, 114 (2): 181–90. PMID 12887920. S2CID 17145731. doi:10.1016/s0092-8674(03)00521-x.
^ Leo E, Deveraux QL, Buchholtz C, Welsh K, Matsuzawa S, Stennicke HR, Salvesen GS, Reed JC. TRAF1 is a substrate of caspases activated during tumor necrosis factor receptor-alpha-induced apoptosis. J. Biol. Chem. March 2001, 276 (11): 8087–93. PMID 11098060. doi:10.1074/jbc.M009450200 .
^ Oukka M, Kim ST, Lugo G, Sun J, Wu LC, Glimcher LH. A mammalian homolog of Drosophila schnurri, KRC, regulates TNF receptor-driven responses and interacts with TRAF2. Mol. Cell. January 2002, 9 (1): 121–31. PMID 11804591. doi:10.1016/s1097-2765(01)00434-8 .
^ Galibert L, Tometsko ME, Anderson DM, Cosman D, Dougall WC. The involvement of multiple tumor necrosis factor receptor (TNFR)-associated factors in the signaling mechanisms of receptor activator of NF-kappaB, a member of the TNFR superfamily. J. Biol. Chem. Dec 1998, 273 (51): 34120–7. PMID 9852070. doi:10.1074/jbc.273.51.34120 .
^ Kim HH, Lee DE, Shin JN, Lee YS, Jeon YM, Chung CH, Ni J, Kwon BS, Lee ZH. Receptor activator of NF-kappaB recruits multiple TRAF family adaptors and activates c-Jun N-terminal kinase. FEBS Lett. January 1999, 443 (3): 297–302. PMID 10025951. S2CID 46210019. doi:10.1016/s0014-5793(98)01731-1 .
^ Song HY, Rothe M, Goeddel DV. The tumor necrosis factor-inducible zinc finger protein A20 interacts with TRAF1/TRAF2 and inhibits NF-kappaB activation. Proc. Natl. Acad. Sci. U.S.A. June 1996, 93 (13): 6721–5. Bibcode:1996PNAS...93.6721S. PMC 39093 . PMID 8692885. doi:10.1073/pnas.93.13.6721 .
^ Heyninck K, Beyaert R. The cytokine-inducible zinc finger protein A20 inhibits IL-1-induced NF-kappaB activation at the level of TRAF6. FEBS Lett. January 1999, 442 (2–3): 147–50. PMID 9928991. S2CID 19072203. doi:10.1016/s0014-5793(98)01645-7 .
^ Lee SY, Lee SY, Choi Y. TRAF-interacting protein (TRIP): a novel component of the tumor necrosis factor receptor (TNFR)- and CD30-TRAF signaling complexes that inhibits TRAF2-mediated NF-kappaB activation. J. Exp. Med. April 1997, 185 (7): 1275–85. PMC 2196258 . PMID 9104814. doi:10.1084/jem.185.7.1275.
^ Bouwmeester T, Bauch A, Ruffner H, Angrand PO, Bergamini G, Croughton K, Cruciat C, Eberhard D, Gagneur J, Ghidelli S, Hopf C, Huhse B, Mangano R, Michon AM, Schirle M, Schlegl J, Schwab M, Stein MA, Bauer A, Casari G, Drewes G, Gavin AC, Jackson DB, Joberty G, Neubauer G, Rick J, Kuster B, Superti-Furga G. A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway. Nat. Cell Biol. February 2004, 6 (2): 97–105. PMID 14743216. S2CID 11683986. doi:10.1038/ncb1086.
^ Takeuchi M, Rothe M, Goeddel DV. Anatomy of TRAF2. Distinct domains for nuclear factor-kappaB activation and association with tumor necrosis factor signaling proteins. J. Biol. Chem. August 1996, 271 (33): 19935–42. PMID 8702708. doi:10.1074/jbc.271.33.19935 .
^ ^21.0 ^21.1 ^21.2 Abdul-Sater AA, Edilova MI, Clouthier DL, Mbanwi A, Kremmer E, Watts TH. The signaling adaptor TRAF1 negatively regulates Toll-like receptor signaling and this underlies its role in rheumatic disease. Nat. Immunol. November 2016, 18 (1): 26–35. PMID 27893701. S2CID 19487408. doi:10.1038/ni.3618.

外部链接

醫學主題詞表（MeSH）：TRAF1

[refGRCh38Ensembl-1] 1.0 ^1.1 ^1.2 GRCh38: Ensembl release 89: ENSG00000056558 - Ensembl, May 2017

[refGRCm38Ensembl-2] 2.0 ^2.1 ^2.2 GRCm38: Ensembl release 89: ENSMUSG00000026875 - Ensembl, May 2017

[3] Human PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] Mouse PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8069916-5] Rothe M, Wong SC, Henzel WJ, Goeddel DV. A novel family of putative signal transducers associated with the cytoplasmic domain of the 75 kDa tumor necrosis factor receptor. Cell. September 1994, 78 (4): 681–92. PMID 8069916. S2CID 28055231. doi:10.1016/0092-8674(94)90532-0.

[pmid9384571-6] 6.0 ^6.1 Roy N, Deveraux QL, Takahashi R, Salvesen GS, Reed JC. The c-IAP-1 and c-IAP-2 proteins are direct inhibitors of specific caspases. EMBO J. Dec 1997, 16 (23): 6914–25. PMC 1170295 . PMID 9384571. doi:10.1093/emboj/16.23.6914.

[pmid11907583-7] 7.0 ^7.1 Li X, Yang Y, Ashwell JD. TNF-RII and c-IAP1 mediate ubiquitination and degradation of TRAF2. Nature. March 2002, 416 (6878): 345–7. Bibcode:2002Natur.416..345L. PMID 11907583. S2CID 4325926. doi:10.1038/416345a.

[pmid8943045-8] Shu HB, Takeuchi M, Goeddel DV. The tumor necrosis factor receptor 2 signal transducers TRAF2 and c-IAP1 are components of the tumor necrosis factor receptor 1 signaling complex. Proc. Natl. Acad. Sci. U.S.A. November 1996, 93 (24): 13973–8. Bibcode:1996PNAS...9313973S. PMC 19479 . PMID 8943045. doi:10.1073/pnas.93.24.13973 .

[pmid9208847-9] Shu HB, Halpin DR, Goeddel DV. Casper is a FADD- and caspase-related inducer of apoptosis. Immunity. June 1997, 6 (6): 751–63. PMID 9208847. doi:10.1016/s1074-7613(00)80450-1 .

[pmid10837247-10] Kataoka T, Budd RC, Holler N, Thome M, Martinon F, Irmler M, Burns K, Hahne M, Kennedy N, Kovacsovics M, Tschopp J. The caspase-8 inhibitor FLIP promotes activation of NF-kappaB and Erk signaling pathways. Curr. Biol. June 2000, 10 (11): 640–8. PMID 10837247. S2CID 14819939. doi:10.1016/s0960-9822(00)00512-1 .

[pmid12887920-11] Micheau O, Tschopp J. Induction of TNF receptor I-mediated apoptosis via two sequential signaling complexes (PDF). Cell. July 2003, 114 (2): 181–90. PMID 12887920. S2CID 17145731. doi:10.1016/s0092-8674(03)00521-x.

[pmid11098060-12] Leo E, Deveraux QL, Buchholtz C, Welsh K, Matsuzawa S, Stennicke HR, Salvesen GS, Reed JC. TRAF1 is a substrate of caspases activated during tumor necrosis factor receptor-alpha-induced apoptosis. J. Biol. Chem. March 2001, 276 (11): 8087–93. PMID 11098060. doi:10.1074/jbc.M009450200 .

[pmid11804591-13] Oukka M, Kim ST, Lugo G, Sun J, Wu LC, Glimcher LH. A mammalian homolog of Drosophila schnurri, KRC, regulates TNF receptor-driven responses and interacts with TRAF2. Mol. Cell. January 2002, 9 (1): 121–31. PMID 11804591. doi:10.1016/s1097-2765(01)00434-8 .

[pmid9852070-14] Galibert L, Tometsko ME, Anderson DM, Cosman D, Dougall WC. The involvement of multiple tumor necrosis factor receptor (TNFR)-associated factors in the signaling mechanisms of receptor activator of NF-kappaB, a member of the TNFR superfamily. J. Biol. Chem. Dec 1998, 273 (51): 34120–7. PMID 9852070. doi:10.1074/jbc.273.51.34120 .

[pmid10025951-15] Kim HH, Lee DE, Shin JN, Lee YS, Jeon YM, Chung CH, Ni J, Kwon BS, Lee ZH. Receptor activator of NF-kappaB recruits multiple TRAF family adaptors and activates c-Jun N-terminal kinase. FEBS Lett. January 1999, 443 (3): 297–302. PMID 10025951. S2CID 46210019. doi:10.1016/s0014-5793(98)01731-1 .

[pmid8692885-16] Song HY, Rothe M, Goeddel DV. The tumor necrosis factor-inducible zinc finger protein A20 interacts with TRAF1/TRAF2 and inhibits NF-kappaB activation. Proc. Natl. Acad. Sci. U.S.A. June 1996, 93 (13): 6721–5. Bibcode:1996PNAS...93.6721S. PMC 39093 . PMID 8692885. doi:10.1073/pnas.93.13.6721 .

[pmid9928991-17] Heyninck K, Beyaert R. The cytokine-inducible zinc finger protein A20 inhibits IL-1-induced NF-kappaB activation at the level of TRAF6. FEBS Lett. January 1999, 442 (2–3): 147–50. PMID 9928991. S2CID 19072203. doi:10.1016/s0014-5793(98)01645-7 .

[pmid9104814-18] Lee SY, Lee SY, Choi Y. TRAF-interacting protein (TRIP): a novel component of the tumor necrosis factor receptor (TNFR)- and CD30-TRAF signaling complexes that inhibits TRAF2-mediated NF-kappaB activation. J. Exp. Med. April 1997, 185 (7): 1275–85. PMC 2196258 . PMID 9104814. doi:10.1084/jem.185.7.1275.

[pmid14743216-19] Bouwmeester T, Bauch A, Ruffner H, Angrand PO, Bergamini G, Croughton K, Cruciat C, Eberhard D, Gagneur J, Ghidelli S, Hopf C, Huhse B, Mangano R, Michon AM, Schirle M, Schlegl J, Schwab M, Stein MA, Bauer A, Casari G, Drewes G, Gavin AC, Jackson DB, Joberty G, Neubauer G, Rick J, Kuster B, Superti-Furga G. A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway. Nat. Cell Biol. February 2004, 6 (2): 97–105. PMID 14743216. S2CID 11683986. doi:10.1038/ncb1086.

[pmid8702708-20] Takeuchi M, Rothe M, Goeddel DV. Anatomy of TRAF2. Distinct domains for nuclear factor-kappaB activation and association with tumor necrosis factor signaling proteins. J. Biol. Chem. August 1996, 271 (33): 19935–42. PMID 8702708. doi:10.1074/jbc.271.33.19935 .

[pmid27893701-21] 21.0 ^21.1 ^21.2 Abdul-Sater AA, Edilova MI, Clouthier DL, Mbanwi A, Kremmer E, Watts TH. The signaling adaptor TRAF1 negatively regulates Toll-like receptor signaling and this underlies its role in rheumatic disease. Nat. Immunol. November 2016, 18 (1): 26–35. PMID 27893701. S2CID 19487408. doi:10.1038/ni.3618.

[1]

[2]

[3]

[4]

[5]

[6]

[7]

[8]

[9]

[10]

[11]

[12]

[13]

[14]

[15]

[16]

[17]

[18]

[19]

[20]

[21]