“我们建议谨慎将对整个基因组variation的总结性分析结果解读为differential基因流。We argue that converting genomic patterns into useful inferences about hybridization will ultimately require models and methods that directly incorporate key ingredients of speciation, including the dynamic nature of gene flow, selection acting in hybrid populations and recombination rate variation.”
"HyDe所预测的γ（i.e. inheritance parameter; quantifies the genomic contributions of the parents to the hybrid）十分robust且准确，而structure和ADMIXTURE尤其在parental contribution不对等（i.e.γ接近于0时）时无法识别杂交。"
"使用structure得出的后验分布常呈多峰状，致使难以解读。"
系统发生学中用STRUCTURE法检验杂交的注意事项：Pang and Zhang., 2024 [3]
^Moeckel, Camille; Mareboina, Manvita; Konnaris, Maxwell A.; Chan, Candace S.Y.; Mouratidis, Ioannis; Montgomery, Austin; Chantzi, Nikol; Pavlopoulos, Georgios A.; Georgakopoulos-Soares, Ilias. A survey of k-mer methods and applications in bioinformatics. Computational and Structural Biotechnology Journal. 2024-12, 23: 2289–2303. doi:10.1016/j.csbj.2024.05.025.
^Kong, Sungsik; Kubatko, Laura S. Comparative Performance of Popular Methods for Hybrid Detection using Genomic Data. Systematic Biology. 2021-09-01, 70 (5): 891–907. doi:https://doi.org/10.1093/sysbio/syaa092请检查|doi=值 (帮助).
