User:Fang-Chia Chang

Fang-Chia Chang (張芳嘉)
国籍	臺灣ese
教育程度	PhD, 德州大學醫學分部
母校	高雄醫學院 (學士) 國立成功大學 (碩士)
职业	特聘教授, 神經科學家
活跃时期	2000年代–至今
雇主	國立臺灣大學
奖项	國家新創獎 (多次) 傑出教學獎 (多次)
网站	www.vm.ntu.edu.tw/DVM/teachers1/teacher26.html

張芳嘉 (Fang-Chia Chang) 是一位臺灣的神經科學家和藥理學家，目前擔任國立臺灣大學（NTU）獸醫學系特聘教授。他是睡眠生理學、睡眠醫學和神經藥理學領域的權威專家。他曾於2020年至2023年擔任臺大獸醫學院院長。

教育與職涯

張教授於1989年獲得高雄醫學院藥學學士學位，並於1991年獲得國立成功大學藥理學碩士學位。 隨後，他在德州大學醫學分部（University of Texas Medical Branch at Galveston）獲得神經科學博士學位，專攻睡眠研究。

他的學術生涯始於臺灣臺中市的中國醫藥大學，從助理教授晉升至副教授。2005年，他加入國立臺灣大學獸醫學院。 他於2020年至2023年擔任獸醫學院院長。

他目前在臺大擔任多項領導職務：

• 神經生物學與認知科學研究中心主任。
• 臺灣國際研究生學程—跨領域神經科學組（TIGP-INS）主席。

研究領域

張教授的研究主要集中於睡眠調節的潛在神經生理機制，以及與各種神經和精神疾病相關的睡眠障礙的發病機制。 他的研究涵蓋以下疾病：

• 阿茲海默症
• 帕金森氏症
• 憂鬱症與焦慮症
• 創傷後壓力症候群（PTSD）

他特別以探索針灸和草藥化合物等傳統中醫對治療失眠和壓力引起的睡眠紊亂的影響而聞名。他的團隊也致力於開發新型治療化合物，例如J4，該化合物在散發性阿茲海默症的小鼠模型中顯示出希望，可逆轉認知缺陷並使睡眠模式正常化。

榮譽與獎項

張教授因其對教育和研究的貢獻獲得了多項榮譽，包括：

• 國家新創獎（多次）
• 國立臺灣大學傑出教學獎（多次）
• 國立臺灣大學教學優良獎（多次）
• 國立臺灣大學傑出導師獎
• 臺灣獸醫菁英教學研究獎 (2014)

代表性著作

• Hsieh, Y. J., Chang, F. C., Liu, C. H., et al. (2025). Histological and electrophysiological effects of sulbactam and valproate in the PTZ-induced epileptic rat model. Epilepsy Research, 218, 107676. doi:10.1016/j.eplepsyres.2025.107676
• Chang, F. C., Liu, C. H., Liao, W. C., et al. (2025). Sulbactam: a β-lactam drug with neuroprotective effects in epilepsy. Neurology International, 17(1), 135. doi:10.3390/neurolint17090135
• Chiu, Y. C., Yi, P. L., & Chang, F. C. (2025). Differential effects of light spectra on sleep architecture and melatonin in rats. Brain Sciences, 15(5), 445. doi:10.3390/brainsci15050445
• Wu, Y. J., Yi, P. L., & Chang, F. C. (2025). Effects of acupuncture at ST36 (Zusanli) on pain and associated sleep disturbance. Journal of Traditional and Complementary Medicine. doi:10.1016/j.jtcme.2025.03.002
• Lo, Y., Yi, P. L., Hsiao, Y. T., Lee, T. Y., & Chang, F. C. (2023). A prolonged stress rat model recapitulates some PTSD-like changes in sleep and neuronal connectivity. Communications Biology, 6(1), 716. doi:10.1038/s42003-023-05090-9
• Lee, T. Y., Yi, P. L., & Chang, F. C. (2023). Hypocretin role in posttraumatic stress disorder-like behaviors induced by a novel stress protocol in mice. Frontiers in Psychiatry, 14, 1196994. doi:10.3389/fpsyt.2023.1196994
• Lo, Y., Yi, P. L., Hsiao, Y. T., & Chang, F. C. (2022). Hypocretin in locus coeruleus and dorsal raphe nucleus mediates inescapable footshock stimulation (IFS)-induced REM sleep alteration. Sleep, 45(3). doi:10.1093/sleep/zsab301
• Li, I. C., Chang, F. C., Kuo, C. C., Chu, H. T., Li, T. J., & Chen, C. C. (2022). Pilot study: Nutritional and preclinical safety investigation of fermented hispidin-enriched Sanghuangporus sanhuang mycelia: a promising functional food material to improve sleep. Frontiers in Nutrition, 8, 788965. doi:10.3389/fnut.2021.788965
• Li, I. C., Lin, T. W., Lee, T. Y., et al. (2021). Oral delivered Armillaria mellea promotes non-rapid eye movement and rapid eye movement sleep in rats. Journal of Fungi, 7(5), 371. doi:10.3390/jof7050371
• Hsiao, Y. T., Chen, T. C., Yu, P. H., et al. (2020). Connectivity between nidopallium caudolateral and visual pathways in color perception of zebra finches. Scientific Reports, 10, 19382. doi:10.1038/s41598-020-76542-z

參見

• 國立臺灣大學

Education and Career

Chang received his Bachelor of Science (B.S.) in Pharmacy from Kaohsiung Medical College and a Master of Science (M.S.) in Pharmacology from National Cheng Kung University.^[1] He later earned his Doctor of Philosophy (Ph.D.) in Neuroscience from the University of Texas Medical Branch at Galveston, specializing in sleep research.^[2]

Chang began his academic career at China Medical University in Taichung, Taiwan, where he progressed from Assistant to Associate Professor. In 2005, he joined the faculty at the School of Veterinary Medicine at National Taiwan University (NTU).^[3] He served as the Dean of the School of Veterinary Medicine from 2020 to 2023.^[4]

He also holds several leadership roles at NTU:

• Director of the Neurobiology and Cognitive Science Center.^[5]
• Chair of the Taiwan International Graduate Program in Interdisciplinary Neuroscience (TIGP-INS).^[6]

Research

Chang's research primarily focuses on the underlying neurophysiological mechanisms of sleep regulation and the neuropathogenesis of sleep disturbances associated with various neurological and psychiatric disorders.^[7] His work has investigated conditions such as:

• Alzheimer's disease
• Parkinson's disease
• Depression and Anxiety
• Post-traumatic stress disorder (PTSD)^[8]

He is particularly known for exploring the effects of traditional Chinese medicine, such as Acupuncture and herbal compounds, on the treatment of insomnia and stress-induced sleep disruption. His team has also worked on developing novel therapeutic compounds, such as J4, which has shown promise in mouse models of sporadic Alzheimer's disease by reversing cognitive deficits and normalizing sleep patterns.^[9]

Awards and Recognition

Chang has received numerous awards for his contributions to education and research, including:^[10]

• National Innovator Award (multiple times)
• Outstanding Teaching Award (multiple times, NTU)
• Excellence Teaching Award (multiple times, NTU)
• Outstanding Mentor Award (NTU)
• Elite Award of Teaching & Research in Taiwan Veterinary Medicine (2014)

See also

• National Taiwan University