WS-23

WS-23
识别信息
	IUPAC命名法 N,2,3-trimethyl-2-propan-2-ylbutanamide; ;
CAS号	51115-67-4
PubChem CID	65300;
IUPHAR/BPS	2474;
ChemSpider	58789;
UNII	6QOP5A9489;
ChEBI	CHEBI:169004;
CompTox Dashboard (EPA)	DTXSID40199124 ;
ECHA InfoCard	100.051.778
化学信息
化学式	C10H21NO
摩尔质量	171.28 g·mol−1
3D模型（JSmol）	交互式图像;
	SMILES CC(C)C(C)(C(C)C)C(=O)NC;
	InChI InChI=1S/C10H21NO/c1-7(2)10(5,8(3)4)9(12)11-6/h7-8H,1-6H3,(H,11,12); Key:RWAXQWRDVUOOGG-UHFFFAOYSA-N;

WS-23（甲基二异丙基丙酰胺、2-异丙基-N,2,3-三甲基丁酰胺）是一种有机化合物，化学式为C₁₀H₂₁NO。它可作为所谓的“薄荷醇受体”（TRPM8 钙离子通道）的激活剂（开放剂），但其亲和力相对较低，并且也可能作用于其他靶点^[1]^[2]。它具有类似薄荷醇的清凉效果，常备用作電子煙组分之一^[3]^[4]。

参考文献

^ Behrendt HJ, Germann T, Gillen C, Hatt H, Jostock R. Characterization of the mouse cold-menthol receptor TRPM8 and vanilloid receptor type-1 VR1 using a fluorometric imaging plate reader (FLIPR) assay. British Journal of Pharmacology. February 2004, 141 (4): 737–745. PMC 1574235 . PMID 14757700. doi:10.1038/sj.bjp.0705652.
^ Sherkheli MA, Vogt-Eisele AK, Bura D, Beltrán Márques LR, Gisselmann G, Hatt H. Characterization of selective TRPM8 ligands and their structure activity response (S.A.R) relationship. Journal of Pharmacy & Pharmaceutical Sciences. 2010, 13 (2): 242–253. PMID 20816009. doi:10.18433/j3n88n.
^ Leventhal AM, Tackett AP, Whitted L, Jordt SE, Jabba SV. Ice flavours and non-menthol synthetic cooling agents in e-cigarette products: a review. Tobacco Control. November 2023, 32 (6): 769–777. PMC 9613790 . PMID 35483721. doi:10.1136/tobaccocontrol-2021-057073.
^ Tackett AP, Han DH, Peraza N, Whaley RC, Mason T, Cahn R, Hong K, Pang R, Monterosso J, Page MK, Goniewicz ML, Leventhal AM. Effects of 'Ice' flavoured e-cigarettes with synthetic cooling agent WS-23 or menthol on user-reported appeal and sensory attributes. Tobacco Control. April 2025, 34 (2): 175–182. PMC 11076411 . PMID 37940405. doi:10.1136/tc-2023-058125.

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[1] Behrendt HJ, Germann T, Gillen C, Hatt H, Jostock R. Characterization of the mouse cold-menthol receptor TRPM8 and vanilloid receptor type-1 VR1 using a fluorometric imaging plate reader (FLIPR) assay. British Journal of Pharmacology. February 2004, 141 (4): 737–745. PMC 1574235 . PMID 14757700. doi:10.1038/sj.bjp.0705652.

[2] Sherkheli MA, Vogt-Eisele AK, Bura D, Beltrán Márques LR, Gisselmann G, Hatt H. Characterization of selective TRPM8 ligands and their structure activity response (S.A.R) relationship. Journal of Pharmacy & Pharmaceutical Sciences. 2010, 13 (2): 242–253. PMID 20816009. doi:10.18433/j3n88n.

[3] Leventhal AM, Tackett AP, Whitted L, Jordt SE, Jabba SV. Ice flavours and non-menthol synthetic cooling agents in e-cigarette products: a review. Tobacco Control. November 2023, 32 (6): 769–777. PMC 9613790 . PMID 35483721. doi:10.1136/tobaccocontrol-2021-057073.

[4] Tackett AP, Han DH, Peraza N, Whaley RC, Mason T, Cahn R, Hong K, Pang R, Monterosso J, Page MK, Goniewicz ML, Leventhal AM. Effects of 'Ice' flavoured e-cigarettes with synthetic cooling agent WS-23 or menthol on user-reported appeal and sensory attributes. Tobacco Control. April 2025, 34 (2): 175–182. PMC 11076411 . PMID 37940405. doi:10.1136/tc-2023-058125.

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