4-碘-2-甲基吡啶
| 4-碘-2-甲基吡啶 | |
|---|---|
| |
| 識別 | |
| CAS號 | 22282-65-1 
|
| SMILES |
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| 性質 | |
| 化學式 | C6H6IN |
| 摩爾質量 | 219.02 g·mol−1 |
| 外觀 | 白色固體[1] |
| 熔點 | 42~43 °C[1] |
| 若非註明，所有數據均出自標準狀態（25 ℃，100 kPa）下。 | |
4-碘-2-甲基吡啶是一種碘代芳烴，化學式為C6H6IN。它可由4-溴-2-甲基吡啶和碘化鈉在碘化亞銅和N,N'-二甲基-1,2-環己二胺催化下於1,4-二氧六環中反應製得。[1]4-三甲基錫基-2-甲基吡啶和碘反應，也能得到4-碘-2-甲基吡啶。[2]
它和三甲基矽基乙炔在催化下反應，可以得到2-甲基-4-(2-三甲基矽基乙炔基)吡啶。[3]
參考文獻
[編輯]- ^ 1.0 1.1 1.2 Chen, Mao; et al. Rapid and Efficient Copper-Catalyzed Finkelstein Reaction of (Hetero)Aromatics under Continuous-Flow Conditions. Angewandte Chemie, International Edition (2015), 54(1), 263-266. doi:10.1002/anie.201409595.
- ^ Yamamoto, Yutaka; et al. Studies on organometallic compounds. II. Facile and convenient method for the synthesis of iodoazines through iododestannation of trimethylstannylazines. Chemical & Pharmaceutical Bulletin (1982), 30(5), 1731-1737. doi:10.1248/cpb.30.1731.
- ^ Jaeschke, Georg; et al. Metabotropic Glutamate Receptor 5 Negative Allosteric Modulators: Discovery of 2-Chloro-4-[1-(4-fluorophenyl)-2,5-dimethyl-1H-imidazol-4-ylethynyl]pyridine (Basimglurant, RO4917523), a Promising Novel Medicine for Psychiatric Diseases. Journal of Medicinal Chemistry (2015), 58(3), 1358-1371. doi:10.1021/jm501642c.