促甲状腺激素释放激素受体

促甲状腺激素释放激素受体
識別號
别名	TRHR；, TRH-R, thyrotropin releasing hormone receptor, CHNG7
外部ID	OMIM：188545 MGI：98824 HomoloGene：20707 GeneCards：TRHR
為以下藥物的標靶
	甲狀腺促素釋素
基因位置（人类）
染色体	8號染色體
终止	109,121,565 bp
基因位置（小鼠）
染色体	小鼠15号染色体
终止	44,099,308 bp
RNA表达模式
	查阅更多表达数据
基因本體
分子功能	• G protein-coupled receptor activity; • signal transducer activity; • thyrotropin-releasing hormone receptor activity;
細胞組分	• integral component of membrane; • 细胞膜; • integral component of plasma membrane; • 膜;
生物學過程	• 訊息傳遞; • G protein-coupled receptor signaling pathway;
	Sources:Amigo / QuickGO
直系同源
	7201
	22045
	ENSG00000174417
	ENSMUSG00000038760
	P34981
	P21761
	NM_003301
	NM_013696
	NP_003292
	NP_038724
	維基數據
檢視/編輯人類	檢視/編輯小鼠

促甲状腺激素释放激素受体（英語：thyrotropin-releasing hormone receptor，TRHR），化学式为：C₂₁₃₄H₃₃₃₀O₆₁₉N₅₁₀S₂₆^[6]，是一种与三肽促甲状腺激素释放激素结合的G蛋白偶联受体^[7]^[8]。TRHR表达于脑细胞中，在与TRH结合时会激活磷脂酶C增加细胞内的肌醇三磷酸含量。

参考文献

^ 對促甲状腺激素释放激素受体起作用的藥物；在維基數據上查看/編輯參考.
^ ^2.0 ^2.1 ^2.2 GRCh38: Ensembl release 89: ENSG00000174417 - Ensembl, May 2017
^ ^3.0 ^3.1 ^3.2 GRCm38: Ensembl release 89: ENSMUSG00000038760 - Ensembl, May 2017
^ Human PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Mouse PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Expasy - ProtParam. web.expasy.org. [2025-07-11].
^ Yamada M, Monden T, Konaka S, Mori M. Assignment of human thyrotropin-releasing hormone (TRH) receptor gene to chromosome 8. Somat. Cell Mol. Genet. 1993, 19 (6): 577–80. PMID 8128317. doi:10.1007/BF01233384.
^ Gershengorn MC. Thyrotropin-releasing hormone receptor: cloning and regulation of its expression. Recent Prog. Horm. Res. 1993, 48: 341–63. PMID 8382829.

延伸阅读

Short RE, James LF, Panter KE; et al. Effects of feeding ponderosa pine needles during pregnancy: comparative studies with bison, cattle, goats, and sheep.. J. Anim. Sci. 1993, 70 (11): 3498–504. PMID 1459912.
Yamada M, Iwasaki T, Satoh T; et al. Activation of the thyrotropin-releasing hormone (TRH) receptor by a direct precursor of TRH, TRH-Gly.. Neurosci. Lett. 1996, 196 (1-2): 109–12. PMID 7501234. doi:10.1016/0304-3940(95)11861-P.
Hinuma S, Hosoya M, Ogi K; et al. Molecular cloning and functional expression of a human thyrotropin-releasing hormone (TRH) receptor gene.. Biochim. Biophys. Acta. 1994, 1219 (2): 251–9. PMID 7918619. doi:10.1016/0167-4781(94)90046-9.
Morrison N, Duthie SM, Boyd E; et al. Assignment of the gene encoding the human thyrotropin-releasing hormone receptor to 8q23 by fluorescence in situ hybridization.. Hum. Genet. 1994, 93 (6): 716–8. PMID 8005602.
Yamada M, Monden T, Konaka S, Mori M. Assignment of human thyrotropin-releasing hormone (TRH) receptor gene to chromosome 8.. Somat. Cell Mol. Genet. 1994, 19 (6): 577–80. PMID 8128317. doi:10.1007/BF01233384.
Duthie SM, Taylor PL, Anderson L; et al. Cloning and functional characterisation of the human TRH receptor.. Mol. Cell. Endocrinol. 1994, 95 (1-2): R11–5. PMID 8243797. doi:10.1016/0303-7207(93)90043-J.
Matre V, Karlsen HE, Wright MS; et al. Molecular cloning of a functional human thyrotropin-releasing hormone receptor.. Biochem. Biophys. Res. Commun. 1993, 195 (1): 179–85. PMID 8395824. doi:10.1006/bbrc.1993.2027.
Yamada M, Monden T, Satoh T; et al. Pituitary adenomas of patients with acromegaly express thyrotropin-releasing hormone receptor messenger RNA: cloning and functional expression of the human thyrotropin-releasing hormone receptor gene.. Biochem. Biophys. Res. Commun. 1993, 195 (2): 737–45. PMID 8396925. doi:10.1006/bbrc.1993.2107.
Iwasaki T, Yamada M, Satoh T; et al. Genomic organization and promoter function of the human thyrotropin-releasing hormone receptor gene.. J. Biol. Chem. 1996, 271 (36): 22183–8. PMID 8703031. doi:10.1074/jbc.271.36.22183.
Cook JV, McGregor A, Lee T; et al. A disulfide bonding interaction role for cysteines in the extracellular domain of the thyrotropin-releasing hormone receptor.. Endocrinology. 1996, 137 (7): 2851–8. PMID 8770906. doi:10.1210/en.137.7.2851.
Collu R, Tang J, Castagné J; et al. A novel mechanism for isolated central hypothyroidism: inactivating mutations in the thyrotropin-releasing hormone receptor gene.. J. Clin. Endocrinol. Metab. 1997, 82 (5): 1561–5. PMID 9141550. doi:10.1210/jc.82.5.1561.
Petrou C, Tashjian AH. The thyrotropin-releasing hormone-receptor complex and G11alpha are both internalised into clathrin-coated vesicles.. Cell. Signal. 1999, 10 (8): 553–9. PMID 9794253. doi:10.1016/S0898-6568(97)00190-3.
Matre V, Høvring PI, Orstavik S; et al. Structural and functional organization of the gene encoding the human thyrotropin-releasing hormone receptor.. J. Neurochem. 1999, 72 (1): 40–50. PMID 9886052. doi:10.1046/j.1471-4159.1999.0720040.x.
Kroeger KM, Hanyaloglu AC, Seeber RM; et al. Constitutive and agonist-dependent homo-oligomerization of the thyrotropin-releasing hormone receptor. Detection in living cells using bioluminescence resonance energy transfer.. J. Biol. Chem. 2001, 276 (16): 12736–43. PMID 11278883. doi:10.1074/jbc.M011311200.
Zhu CC, Cook LB, Hinkle PM. Dimerization and phosphorylation of thyrotropin-releasing hormone receptors are modulated by agonist stimulation.. J. Biol. Chem. 2002, 277 (31): 28228–37. PMID 12023974. doi:10.1074/jbc.M204221200.
Hanyaloglu AC, Seeber RM, Kohout TA; et al. Homo- and hetero-oligomerization of thyrotropin-releasing hormone (TRH) receptor subtypes. Differential regulation of beta-arrestins 1 and 2.. J. Biol. Chem. 2003, 277 (52): 50422–30. PMID 12393857. doi:10.1074/jbc.M209340200.
Strausberg RL, Feingold EA, Grouse LH; et al. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.. Proc. Natl. Acad. Sci. U.S.A. 2003, 99 (26): 16899–903. PMC 139241 . PMID 12477932. doi:10.1073/pnas.242603899.
Cook LB, Zhu CC, Hinkle PM. Thyrotropin-releasing hormone receptor processing: role of ubiquitination and proteasomal degradation.. Mol. Endocrinol. 2004, 17 (9): 1777–91. PMID 12805411. doi:10.1210/me.2003-0073.
Igarashi-Migitaka J, Yamada S, Hara M; et al. Gene expression study of thyrotropin releasing hormone (TRH) receptor using RT-PCR: relationship to clinical and immunohistochemical phenotypes in a series of human pituitary adenomas.. Endocr. J. 2004, 50 (4): 459–67. PMID 14599121. doi:10.1507/endocrj.50.459.
Cook LB, Hinkle PM. Fate of internalized thyrotropin-releasing hormone receptors monitored with a timer fusion protein.. Endocrinology. 2004, 145 (7): 3095–100. PMID 15117874. doi:10.1210/en.2004-0304.

外部链接

Thyrotropin-Releasing Hormone Receptors. IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. （原始内容存档于2012-09-08）.
醫學主題詞表（MeSH）：Receptors,+Thyrotropin-Releasing+Hormone

[1] 對促甲状腺激素释放激素受体起作用的藥物；在維基數據上查看/編輯參考.

[refGRCh38Ensembl-2] 2.0 ^2.1 ^2.2 GRCh38: Ensembl release 89: ENSG00000174417 - Ensembl, May 2017

[refGRCm38Ensembl-3] 3.0 ^3.1 ^3.2 GRCm38: Ensembl release 89: ENSMUSG00000038760 - Ensembl, May 2017

[4] Human PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.

[5] Mouse PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.

[6] Expasy - ProtParam. web.expasy.org. [2025-07-11].

[pmid8128317-7] Yamada M, Monden T, Konaka S, Mori M. Assignment of human thyrotropin-releasing hormone (TRH) receptor gene to chromosome 8. Somat. Cell Mol. Genet. 1993, 19 (6): 577–80. PMID 8128317. doi:10.1007/BF01233384.

[pmid8382829-8] Gershengorn MC. Thyrotropin-releasing hormone receptor: cloning and regulation of its expression. Recent Prog. Horm. Res. 1993, 48: 341–63. PMID 8382829.

[1]

[2]

[3]

[4]

[5]

[6]

[7]

[8]