ALDH1A2

ALDH1A2
已知的結構
PDB	直系同源搜索: PDBe RCSB
PDBID列表
	4X2Q
識別號
别名	ALDH1A2；, RALDH(II), RALDH2, RALDH2-T, aldehyde dehydrogenase 1 family member A2
外部ID	OMIM：603687 MGI：107928 HomoloGene：68368 GeneCards：ALDH1A2
基因位置（人类）
染色体	15號染色體
终止	58,497,866 bp
基因位置（小鼠）
染色体	小鼠9号染色体
终止	71,203,525 bp
基因本體
分子功能	• oxidoreductase activity; • aldehyde dehydrogenase (NAD+) activity; • retinal binding; • retinal dehydrogenase activity; • 3-chloroallyl aldehyde dehydrogenase activity; • oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor;
細胞組分	• 細胞質; • 细胞质基质; • 细胞质的核周区域;
生物學過程	• cellular response to retinoic acid; • proximal/distal pattern formation; • response to cytokine; • 垂体的发生; • response to estradiol; • 9-cis-retinoic acid biosynthetic process; • neural crest cell development; • cardiac muscle tissue development; • lung development; • 肾的发生; • retinol metabolic process; • heart morphogenesis; • hindbrain development; • retinoic acid metabolic process; • retinal metabolic process; • embryonic camera-type eye development; • retinoic acid biosynthetic process; • response to vitamin A; • face development; • positive regulation of gene expression; • retinoic acid receptor signaling pathway; • blood vessel development; • embryonic limb morphogenesis; • ureter maturation; • neural tube development; • neuron differentiation; • positive regulation of cell population proliferation; • regulation of endothelial cell proliferation; • positive regulation of apoptotic process; • 胰腺发育; • determination of bilateral symmetry; • vitamin A metabolic process; • liver development; • forebrain development; • camera-type eye development; • 代謝; • morphogenesis of embryonic epithelium; • embryonic digestive tract development; • embryonic forelimb morphogenesis; • anterior/posterior pattern specification; • negative regulation of cell population proliferation; • midgut development; • retinoic acid receptor signaling pathway involved in somitogenesis; • protein homotetramerization;
	Sources:Amigo / QuickGO
直系同源
	8854
	19378
	ENSG00000128918
	ENSMUSG00000013584
	O94788
	Q62148
	NM_170697; NM_001206897; NM_003888; NM_170696
	NM_009022
	NP_001193826; NP_003879; NP_733797; NP_733798
	NP_033048
	維基數據
檢視/編輯人類	檢視/編輯小鼠

醛脱氢酶1家族成员A2（英語：Aldehyde dehydrogenase 1 family, member A2），简称为ALDH1A2，或称为视黄醛脱氢酶2（简写为RALDH2），是在人体内一种由ALDH1A2基因编码的酶。^[5]^[6]此蛋白为醛脱氢酶蛋白家族成员，是负责催化视黄酸到视黄醛的合成的酶。视黄酸是维生素A（即视黄醇）的活性衍生物，是一种旁分泌激素信号分子，主要作用于发育中的组织和成年组织中。^[7]对小鼠中类似基因的研究表明，这种酶和细胞色素CYP26A1同时确立局部胚胎组织中的视黄酸浓度，促进后部器官发育和防止脊柱裂。ALDH1A2基因已确认有三种可编码不同亚型蛋白的转录变异体。^[6]

参考文献

^ ^1.0 ^1.1 ^1.2 GRCh38: Ensembl release 89: ENSG00000128918 - Ensembl, May 2017
^ ^2.0 ^2.1 ^2.2 GRCm38: Ensembl release 89: ENSMUSG00000013584 - Ensembl, May 2017
^ Human PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Mouse PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.
^ TAL1 and LIM-Only Proteins Synergistically Induce Retinaldehyde Dehydrogenase 2 Expression in T-Cell Acute Lymphoblastic Leukemia by Acting as Cofactors for GATA3. Mol Cell Biol. Dec 1998, 18 (12): 6939–50. PMC 109277 . PMID 9819382.
^ ^6.0 ^6.1 Entrez Gene: ALDH1A2 aldehyde dehydrogenase 1 family, member A2.
^ Duester G. Retinoic Acid Synthesis and Signaling during Early Organogenesis. Cell. September 2008, 134 (6): 921–31. PMC 2632951 . PMID 18805086. doi:10.1016/j.cell.2008.09.002.

拓展阅读

Human ALDH1A2 genome location and ALDH1A2 gene details page in the UCSC Genome Browser（英语：UCSC Genome Browser）.
Wang X, Penzes P, Napoli JL. Cloning of a cDNA encoding an aldehyde dehydrogenase and its expression in Escherichia coli. Recognition of retinal as substrate. The Journal of Biological Chemistry. July 1996, 271 (27): 16288–16293. PMID 8663198. doi:10.1074/jbc.271.27.16288 .
Zhao D, McCaffery P, Ivins KJ, Neve RL, Hogan P, Chin WW, Dräger UC. Molecular identification of a major retinoic-acid-synthesizing enzyme, a retinaldehyde-specific dehydrogenase. European Journal of Biochemistry. August 1996, 240 (1): 15–22. PMID 8797830. doi:10.1111/j.1432-1033.1996.0015h.x.
Niederreither K, Subbarayan V, Dollé P, Chambon P. Embryonic retinoic acid synthesis is essential for early mouse post-implantation development. Nature Genetics. April 1999, 21 (4): 444–448. PMID 10192400. S2CID 35572750. doi:10.1038/7788.
Niederreither K, Abu-Abed S, Schuhbaur B, Petkovich M, Chambon P, Dollé P. Genetic evidence that oxidative derivatives of retinoic acid are not involved in retinoid signaling during mouse development. Nature Genetics. May 2002, 31 (1): 84–88. PMID 11953746. S2CID 13607364. doi:10.1038/ng876.
Strausberg, RL; Feingold, EA; Grouse, LH. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proceedings of the National Academy of Sciences. 2002-12-24, 99 (26). ISSN 0027-8424. PMC 139241 . PMID 12477932. doi:10.1073/pnas.242603899 （英语）.
Ota, Toshio; Suzuki, Yutaka; Nishikawa, Tetsuo; Otsuki, Tetsuji; Sugiyama, Tomoyasu; Irie, Ryotaro; Wakamatsu, Ai; Hayashi, Koji; Sato, Hiroyuki; Nagai, Keiichi; Kimura, Kouichi. Complete sequencing and characterization of 21,243 full-length human cDNAs. Nature Genetics. 2004-01, 36 (1). ISSN 1061-4036. doi:10.1038/ng1285 （英语）.
Anderson NL, Polanski M, Pieper R, Gatlin T, Tirumalai RS, Conrads TP, Veenstra TD, Adkins JN, Pounds JG, Fagan R, Lobley A. The human plasma proteome: a nonredundant list developed by combination of four separate sources. Molecular & Cellular Proteomics. April 2004, 3 (4): 311–326. PMID 14718574. doi:10.1074/mcp.M300127-MCP200 .
Gerhard, DS; Wagner, L; Feingold, EA. The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC). Genome Research. 2004-10-15, 14 (10b). ISSN 1088-9051. PMC 528928 . PMID 15489334. doi:10.1101/gr.2596504 （英语）.
Deak KL, Dickerson ME, Linney E, Enterline DS, George TM, Melvin EC, Graham FL, Siegel DG, Hammock P, Mehltretter L, Bassuk AG, Kessler JA, Gilbert JR, Speer MC. Analysis of ALDH1A2, CYP26A1, CYP26B1, CRABP1, and CRABP2 in human neural tube defects suggests a possible association with alleles in ALDH1A2. Birth Defects Research. Part A, Clinical and Molecular Teratology. November 2005, 73 (11): 868–875. PMID 16237707. doi:10.1002/bdra.20183 .
Ribes V, Wang Z, Dollé P, Niederreither K. Retinaldehyde dehydrogenase 2 (RALDH2)-mediated retinoic acid synthesis regulates early mouse embryonic forebrain development by controlling FGF and sonic hedgehog signaling. Development. January 2006, 133 (2): 351–361. PMID 16368932. doi:10.1242/dev.02204 .

[refGRCh38Ensembl-1] 1.0 ^1.1 ^1.2 GRCh38: Ensembl release 89: ENSG00000128918 - Ensembl, May 2017

[refGRCm38Ensembl-2] 2.0 ^2.1 ^2.2 GRCm38: Ensembl release 89: ENSMUSG00000013584 - Ensembl, May 2017

[3] Human PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] Mouse PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9819382-5] TAL1 and LIM-Only Proteins Synergistically Induce Retinaldehyde Dehydrogenase 2 Expression in T-Cell Acute Lymphoblastic Leukemia by Acting as Cofactors for GATA3. Mol Cell Biol. Dec 1998, 18 (12): 6939–50. PMC 109277 . PMID 9819382.

[entrez2-6] 6.0 ^6.1 Entrez Gene: ALDH1A2 aldehyde dehydrogenase 1 family, member A2.

[Duester-7] Duester G. Retinoic Acid Synthesis and Signaling during Early Organogenesis. Cell. September 2008, 134 (6): 921–31. PMC 2632951 . PMID 18805086. doi:10.1016/j.cell.2008.09.002.

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