ALDH1A2

ALDH1A2
已知的結構
PDB	直系同源搜尋: PDBe RCSB
PDBID列表
	4X2Q
識別號
別名	ALDH1A2；, RALDH(II), RALDH2, RALDH2-T, aldehyde dehydrogenase 1 family member A2
外部ID	OMIM：603687 MGI：107928 HomoloGene：68368 GeneCards：ALDH1A2
基因位置（人類）
染色體	15號染色體
終止	58,497,866 bp
基因位置（小鼠）
染色體	小鼠9號染色體
終止	71,203,525 bp
基因本體
分子功能	• oxidoreductase activity; • aldehyde dehydrogenase (NAD+) activity; • retinal binding; • retinal dehydrogenase activity; • 3-chloroallyl aldehyde dehydrogenase activity; • oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor;
細胞組分	• 細胞質; • 細胞質基質; • 細胞質的核周區域;
生物學過程	• cellular response to retinoic acid; • proximal/distal pattern formation; • response to cytokine; • 腦垂腺的發生; • response to estradiol; • 9-cis-retinoic acid biosynthetic process; • neural crest cell development; • cardiac muscle tissue development; • lung development; • 腎的發生; • retinol metabolic process; • heart morphogenesis; • hindbrain development; • retinoic acid metabolic process; • retinal metabolic process; • embryonic camera-type eye development; • retinoic acid biosynthetic process; • response to vitamin A; • face development; • positive regulation of gene expression; • retinoic acid receptor signaling pathway; • blood vessel development; • embryonic limb morphogenesis; • ureter maturation; • neural tube development; • neuron differentiation; • positive regulation of cell population proliferation; • regulation of endothelial cell proliferation; • positive regulation of apoptotic process; • 胰腺發育; • determination of bilateral symmetry; • vitamin A metabolic process; • liver development; • forebrain development; • camera-type eye development; • 代謝; • morphogenesis of embryonic epithelium; • embryonic digestive tract development; • embryonic forelimb morphogenesis; • anterior/posterior pattern specification; • negative regulation of cell population proliferation; • midgut development; • retinoic acid receptor signaling pathway involved in somitogenesis; • protein homotetramerization;
	Sources:Amigo / QuickGO
直系同源
	8854
	19378
	ENSG00000128918
	ENSMUSG00000013584
	O94788
	Q62148
	NM_170697; NM_001206897; NM_003888; NM_170696
	NM_009022
	NP_001193826; NP_003879; NP_733797; NP_733798
	NP_033048
	維基資料
檢視/編輯人類	檢視/編輯小鼠

醛去氫酶1家族成員A2（英語：Aldehyde dehydrogenase 1 family, member A2），簡稱為ALDH1A2，或稱為視黃醛去氫酶2（簡寫為RALDH2），是在人體內一種由ALDH1A2基因編碼的酶。^[5]^[6]此蛋白為醛去氫酶蛋白家族成員，是負責催化視黃酸到視黃醛的合成的酶。視黃酸是維生素A（即視黃醇）的活性衍生物，是一種旁分泌激素傳訊分子，主要作用於發育中的組織和成年組織中。^[7]對小鼠中類似基因的研究表明，這種酶和細胞色素CYP26A1同時確立局部胚胎組織中的視黃酸濃度，促進後部器官發育和防止脊柱裂。ALDH1A2基因已確認有三種可編碼不同亞型蛋白的轉錄變異體。^[6]

參考文獻

^ ^1.0 ^1.1 ^1.2 GRCh38: Ensembl release 89: ENSG00000128918 - Ensembl, May 2017
^ ^2.0 ^2.1 ^2.2 GRCm38: Ensembl release 89: ENSMUSG00000013584 - Ensembl, May 2017
^ Human PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Mouse PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.
^ TAL1 and LIM-Only Proteins Synergistically Induce Retinaldehyde Dehydrogenase 2 Expression in T-Cell Acute Lymphoblastic Leukemia by Acting as Cofactors for GATA3. Mol Cell Biol. Dec 1998, 18 (12): 6939–50. PMC 109277 . PMID 9819382.
^ ^6.0 ^6.1 Entrez Gene: ALDH1A2 aldehyde dehydrogenase 1 family, member A2.
^ Duester G. Retinoic Acid Synthesis and Signaling during Early Organogenesis. Cell. September 2008, 134 (6): 921–31. PMC 2632951 . PMID 18805086. doi:10.1016/j.cell.2008.09.002.

拓展閱讀

Human ALDH1A2 genome location and ALDH1A2 gene details page in the UCSC Genome Browser（英語：UCSC Genome Browser）.
Wang X, Penzes P, Napoli JL. Cloning of a cDNA encoding an aldehyde dehydrogenase and its expression in Escherichia coli. Recognition of retinal as substrate. The Journal of Biological Chemistry. July 1996, 271 (27): 16288–16293. PMID 8663198. doi:10.1074/jbc.271.27.16288 .
Zhao D, McCaffery P, Ivins KJ, Neve RL, Hogan P, Chin WW, Dräger UC. Molecular identification of a major retinoic-acid-synthesizing enzyme, a retinaldehyde-specific dehydrogenase. European Journal of Biochemistry. August 1996, 240 (1): 15–22. PMID 8797830. doi:10.1111/j.1432-1033.1996.0015h.x.
Niederreither K, Subbarayan V, Dollé P, Chambon P. Embryonic retinoic acid synthesis is essential for early mouse post-implantation development. Nature Genetics. April 1999, 21 (4): 444–448. PMID 10192400. S2CID 35572750. doi:10.1038/7788.
Niederreither K, Abu-Abed S, Schuhbaur B, Petkovich M, Chambon P, Dollé P. Genetic evidence that oxidative derivatives of retinoic acid are not involved in retinoid signaling during mouse development. Nature Genetics. May 2002, 31 (1): 84–88. PMID 11953746. S2CID 13607364. doi:10.1038/ng876.
Strausberg, RL; Feingold, EA; Grouse, LH. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proceedings of the National Academy of Sciences. 2002-12-24, 99 (26). ISSN 0027-8424. PMC 139241 . PMID 12477932. doi:10.1073/pnas.242603899 （英語）.
Ota, Toshio; Suzuki, Yutaka; Nishikawa, Tetsuo; Otsuki, Tetsuji; Sugiyama, Tomoyasu; Irie, Ryotaro; Wakamatsu, Ai; Hayashi, Koji; Sato, Hiroyuki; Nagai, Keiichi; Kimura, Kouichi. Complete sequencing and characterization of 21,243 full-length human cDNAs. Nature Genetics. 2004-01, 36 (1). ISSN 1061-4036. doi:10.1038/ng1285 （英語）.
Anderson NL, Polanski M, Pieper R, Gatlin T, Tirumalai RS, Conrads TP, Veenstra TD, Adkins JN, Pounds JG, Fagan R, Lobley A. The human plasma proteome: a nonredundant list developed by combination of four separate sources. Molecular & Cellular Proteomics. April 2004, 3 (4): 311–326. PMID 14718574. doi:10.1074/mcp.M300127-MCP200 .
Gerhard, DS; Wagner, L; Feingold, EA. The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC). Genome Research. 2004-10-15, 14 (10b). ISSN 1088-9051. PMC 528928 . PMID 15489334. doi:10.1101/gr.2596504 （英語）.
Deak KL, Dickerson ME, Linney E, Enterline DS, George TM, Melvin EC, Graham FL, Siegel DG, Hammock P, Mehltretter L, Bassuk AG, Kessler JA, Gilbert JR, Speer MC. Analysis of ALDH1A2, CYP26A1, CYP26B1, CRABP1, and CRABP2 in human neural tube defects suggests a possible association with alleles in ALDH1A2. Birth Defects Research. Part A, Clinical and Molecular Teratology. November 2005, 73 (11): 868–875. PMID 16237707. doi:10.1002/bdra.20183 .
Ribes V, Wang Z, Dollé P, Niederreither K. Retinaldehyde dehydrogenase 2 (RALDH2)-mediated retinoic acid synthesis regulates early mouse embryonic forebrain development by controlling FGF and sonic hedgehog signaling. Development. January 2006, 133 (2): 351–361. PMID 16368932. doi:10.1242/dev.02204 .

[refGRCh38Ensembl-1] 1.0 ^1.1 ^1.2 GRCh38: Ensembl release 89: ENSG00000128918 - Ensembl, May 2017

[refGRCm38Ensembl-2] 2.0 ^2.1 ^2.2 GRCm38: Ensembl release 89: ENSMUSG00000013584 - Ensembl, May 2017

[3] Human PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] Mouse PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9819382-5] TAL1 and LIM-Only Proteins Synergistically Induce Retinaldehyde Dehydrogenase 2 Expression in T-Cell Acute Lymphoblastic Leukemia by Acting as Cofactors for GATA3. Mol Cell Biol. Dec 1998, 18 (12): 6939–50. PMC 109277 . PMID 9819382.

[entrez2-6] 6.0 ^6.1 Entrez Gene: ALDH1A2 aldehyde dehydrogenase 1 family, member A2.

[Duester-7] Duester G. Retinoic Acid Synthesis and Signaling during Early Organogenesis. Cell. September 2008, 134 (6): 921–31. PMC 2632951 . PMID 18805086. doi:10.1016/j.cell.2008.09.002.

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