HTN1

HTN1
识别号
别名	HTN1；, HIS1, histatin 1
外部ID	OMIM：142701 HomoloGene：88658 GeneCards：HTN1
基因位置（人类） 染色体 4号染色体 基因座 4q13.3 起始 70,050,438 bp 终止 70,058,848 bp
RNA表达模式
查阅更多表达数据
基因本体 分子功能 • 血浆蛋白结合 细胞组分 • 细胞外区域 • 细胞外空间 生物学过程 • biomineral tissue development • defense response to bacterium • defense response to fungus • antimicrobial humoral response • killing of cells of other organism Sources:Amigo / QuickGO
直系同源
物种	人类	小鼠
Entrez	3346	无数据
Ensembl	ENSG00000283046 ​ENSG00000126550	无数据
UniProt	P15515	无数据
mRNA​序列	NM_002159 ​NM_001368990	无数据
蛋白序列	NP_002150 ​NP_001355919	无数据
基因位置​（UCSC）	Chr 4: 70.05 – 70.06 Mb	无数据
PubMed​查找		无数据
维基数据
查看/编辑人类

组氨素1（英语：Histatin-1），是一类由HTN1基因编码的蛋白质，其编码的组氨素1还能降解为组氨素2。组氨素1化学式为：C₁₅₈H₂₁₁O₄₄N₄₅

等位基因	基因	蛋白质
HIS1	HTN1	组氨素 1 → 组氨素 2
HIS2	HTN3	组氨素 3 → 组氨素 4-6

延伸阅读

• Sugiyama K, Ogino T, Ogata K. Rapid purification and characterization of histatins (histidine-rich polypeptides) from human whole saliva.. Arch. Oral Biol. 1990, 35 (6): 415–9. PMID 2372245. doi:10.1016/0003-9969(90)90202-L. 
• Sabatini LM, Azen EA. Histatins, a family of salivary histidine-rich proteins, are encoded by at least two loci (HIS1 and HIS2).. Biochem. Biophys. Res. Commun. 1989, 160 (2): 495–502. PMID 2719677. doi:10.1016/0006-291X(89)92460-1. 
• vanderSpek JC, Wyandt HE, Skare JC; et al. Localization of the genes for histatins to human chromosome 4q13 and tissue distribution of the mRNAs.. Am. J. Hum. Genet. 1989, 45 (3): 381–7. PMC 1683406 . PMID 2773933.  引文格式1维护：显式使用等标签 (link)
• Oppenheim FG, Xu T, McMillian FM; et al. Histatins, a novel family of histidine-rich proteins in human parotid secretion. Isolation, characterization, primary structure, and fungistatic effects on Candida albicans.. J. Biol. Chem. 1988, 263 (16): 7472–7. PMID 3286634.  引文格式1维护：显式使用等标签 (link)
• Oppenheim FG, Yang YC, Diamond RD; et al. The primary structure and functional characterization of the neutral histidine-rich polypeptide from human parotid secretion.. J. Biol. Chem. 1986, 261 (3): 1177–82. PMID 3944083.  引文格式1维护：显式使用等标签 (link)
• Sabatini LM, Ota T, Azen EA. Nucleotide sequence analysis of the human salivary protein genes HIS1 and HIS2, and evolution of the STATH/HIS gene family.. Mol. Biol. Evol. 1993, 10 (3): 497–511. PMID 8336540. 
• Driscoll J, Zuo Y, Xu T; et al. Functional comparison of native and recombinant human salivary histatin 1.. J. Dent. Res. 1996, 74 (12): 1837–44. PMID 8600179. doi:10.1177/00220345950740120601.  引文格式1维护：显式使用等标签 (link)
• Iontcheva I, Oppenheim FG, Offner GD, Troxler RF. Molecular mapping of statherin- and histatin-binding domains in human salivary mucin MG1 (MUC5B) by the yeast two-hybrid system.. J. Dent. Res. 2000, 79 (2): 732–9. PMID 10728974. doi:10.1177/00220345000790020601. 
• Flora B, Gusman H, Helmerhorst EJ; et al. A new method for the isolation of histatins 1, 3, and 5 from parotid secretion using zinc precipitation.. Protein Expr. Purif. 2002, 23 (1): 198–206. PMID 11570863. doi:10.1006/prep.2001.1493.  引文格式1维护：显式使用等标签 (link)
• Tamaki N, Tada T, Morita M, Watanabe T. Comparison of inhibitory activity on calcium phosphate precipitation by acidic proline-rich proteins, statherin, and histatin-1.. Calcif. Tissue Int. 2003, 71 (1): 59–62. PMID 12060866. doi:10.1007/s00223-001-1084-0. 
• Strausberg RL, Feingold EA, Grouse LH; et al. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.. Proc. Natl. Acad. Sci. U.S.A. 2003, 99 (26): 16899–903. PMC 139241 . PMID 12477932. doi:10.1073/pnas.242603899.  引文格式1维护：显式使用等标签 (link)
• Yin A, Margolis HC, Grogan J; et al. Physical parameters of hydroxyapatite adsorption and effect on candidacidal activity of histatins.. Arch. Oral Biol. 2003, 48 (5): 361–8. PMID 12711380. doi:10.1016/S0003-9969(03)00012-8.  引文格式1维护：显式使用等标签 (link)
• Michels AA, Nguyen VT, Fraldi A; et al. MAQ1 and 7SK RNA interact with CDK9/cyclin T complexes in a transcription-dependent manner.. Mol. Cell. Biol. 2003, 23 (14): 4859–69. PMC 162212 . PMID 12832472. doi:10.1128/MCB.23.14.4859-4869.2003.  引文格式1维护：显式使用等标签 (link)
• Gerhard DS, Wagner L, Feingold EA; et al. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).. Genome Res. 2004, 14 (10B): 2121–7. PMC 528928 . PMID 15489334. doi:10.1101/gr.2596504.  引文格式1维护：显式使用等标签 (link)
• Bruno LS, Li X, Wang L; et al. Two-hybrid analysis of human salivary mucin MUC7 interactions.. Biochim. Biophys. Acta. 2005, 1746 (1): 65–72. PMID 16203048. doi:10.1016/j.bbamcr.2005.08.007.  引文格式1维护：显式使用等标签 (link)
• Cabras T, Fanali C, Monteiro JA; et al. Tyrosine polysulfation of human salivary histatin 1. A post-translational modification specific of the submandibular gland.. J. Proteome Res. 2007, 6 (7): 2472–80. PMID 17503797. doi:10.1021/pr0700706.  引文格式1维护：显式使用等标签 (link)