HTN1

HTN1
識別號
別名	HTN1；, HIS1, histatin 1
外部ID	OMIM：142701 HomoloGene：88658 GeneCards：HTN1
基因位置（人類）
染色體	4號染色體
終止	70,058,848 bp
RNA表達模式
	查閱更多表達數據
基因本體
分子功能	• 血漿蛋白結合;
細胞組分	• 細胞外區域; • 細胞外空間;
生物學過程	• biomineral tissue development; • defense response to bacterium; • defense response to fungus; • antimicrobial humoral response; • killing of cells of other organism;
	Sources:Amigo / QuickGO
直系同源
	3346
	無數據
	ENSG00000283046; ENSG00000126550
	無數據
	P15515
	無數據
	NM_002159; NM_001368990
	無數據
	NP_002150; NP_001355919
	無數據
	維基數據
檢視/編輯人類

組氨素1（英語：Histatin-1），是一類由HTN1基因編碼的蛋白質^[3]，其編碼的組氨素1還能降解為組氨素2。組氨素1化學式為：C₁₅₈H₂₁₁O₄₄N₄₅^[4]

等位基因	基因	蛋白質
HIS1	HTN1	組氨素 1 → 組氨素 2
HIS2	HTN3	組氨素 3 → 組氨素 4-6

參考文獻

^ ^1.0 ^1.1 ^1.2 GRCh38: Ensembl release 89: ENSG00000283046、ENSG00000126550 - Ensembl, May 2017
^ Human PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Entrez Gene: HTN1 histatin 1. （原始內容存檔於2019-10-17）.
^ Expasy - ProtParam. web.expasy.org. [2025-07-11].

延伸閱讀

Sugiyama K, Ogino T, Ogata K. Rapid purification and characterization of histatins (histidine-rich polypeptides) from human whole saliva.. Arch. Oral Biol. 1990, 35 (6): 415–9. PMID 2372245. doi:10.1016/0003-9969(90)90202-L.
Sabatini LM, Azen EA. Histatins, a family of salivary histidine-rich proteins, are encoded by at least two loci (HIS1 and HIS2).. Biochem. Biophys. Res. Commun. 1989, 160 (2): 495–502. PMID 2719677. doi:10.1016/0006-291X(89)92460-1.
vanderSpek JC, Wyandt HE, Skare JC; et al. Localization of the genes for histatins to human chromosome 4q13 and tissue distribution of the mRNAs.. Am. J. Hum. Genet. 1989, 45 (3): 381–7. PMC 1683406 . PMID 2773933.
Oppenheim FG, Xu T, McMillian FM; et al. Histatins, a novel family of histidine-rich proteins in human parotid secretion. Isolation, characterization, primary structure, and fungistatic effects on Candida albicans.. J. Biol. Chem. 1988, 263 (16): 7472–7. PMID 3286634.
Oppenheim FG, Yang YC, Diamond RD; et al. The primary structure and functional characterization of the neutral histidine-rich polypeptide from human parotid secretion.. J. Biol. Chem. 1986, 261 (3): 1177–82. PMID 3944083.
Sabatini LM, Ota T, Azen EA. Nucleotide sequence analysis of the human salivary protein genes HIS1 and HIS2, and evolution of the STATH/HIS gene family.. Mol. Biol. Evol. 1993, 10 (3): 497–511. PMID 8336540.
Driscoll J, Zuo Y, Xu T; et al. Functional comparison of native and recombinant human salivary histatin 1.. J. Dent. Res. 1996, 74 (12): 1837–44. PMID 8600179. doi:10.1177/00220345950740120601.
Iontcheva I, Oppenheim FG, Offner GD, Troxler RF. Molecular mapping of statherin- and histatin-binding domains in human salivary mucin MG1 (MUC5B) by the yeast two-hybrid system.. J. Dent. Res. 2000, 79 (2): 732–9. PMID 10728974. doi:10.1177/00220345000790020601.
Flora B, Gusman H, Helmerhorst EJ; et al. A new method for the isolation of histatins 1, 3, and 5 from parotid secretion using zinc precipitation.. Protein Expr. Purif. 2002, 23 (1): 198–206. PMID 11570863. doi:10.1006/prep.2001.1493.
Tamaki N, Tada T, Morita M, Watanabe T. Comparison of inhibitory activity on calcium phosphate precipitation by acidic proline-rich proteins, statherin, and histatin-1.. Calcif. Tissue Int. 2003, 71 (1): 59–62. PMID 12060866. doi:10.1007/s00223-001-1084-0.
Strausberg RL, Feingold EA, Grouse LH; et al. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.. Proc. Natl. Acad. Sci. U.S.A. 2003, 99 (26): 16899–903. PMC 139241 . PMID 12477932. doi:10.1073/pnas.242603899.
Yin A, Margolis HC, Grogan J; et al. Physical parameters of hydroxyapatite adsorption and effect on candidacidal activity of histatins.. Arch. Oral Biol. 2003, 48 (5): 361–8. PMID 12711380. doi:10.1016/S0003-9969(03)00012-8.
Michels AA, Nguyen VT, Fraldi A; et al. MAQ1 and 7SK RNA interact with CDK9/cyclin T complexes in a transcription-dependent manner.. Mol. Cell. Biol. 2003, 23 (14): 4859–69. PMC 162212 . PMID 12832472. doi:10.1128/MCB.23.14.4859-4869.2003.
Gerhard DS, Wagner L, Feingold EA; et al. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).. Genome Res. 2004, 14 (10B): 2121–7. PMC 528928 . PMID 15489334. doi:10.1101/gr.2596504.
Bruno LS, Li X, Wang L; et al. Two-hybrid analysis of human salivary mucin MUC7 interactions.. Biochim. Biophys. Acta. 2005, 1746 (1): 65–72. PMID 16203048. doi:10.1016/j.bbamcr.2005.08.007.
Cabras T, Fanali C, Monteiro JA; et al. Tyrosine polysulfation of human salivary histatin 1. A post-translational modification specific of the submandibular gland.. J. Proteome Res. 2007, 6 (7): 2472–80. PMID 17503797. doi:10.1021/pr0700706.

[refGRCh38Ensembl-1] 1.0 ^1.1 ^1.2 GRCh38: Ensembl release 89: ENSG00000283046、ENSG00000126550 - Ensembl, May 2017

[2] Human PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-3] Entrez Gene: HTN1 histatin 1. （原始內容存檔於2019-10-17）.

[4] Expasy - ProtParam. web.expasy.org. [2025-07-11].

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閱論編成孔毒素（英語：Pore-forming toxin）（TC 1C）
人體抗微生物肽	抗菌肽防禦素皮離蛋白（英語：Dermcidin）組氨素 HTN1 HTN3
蛋白毒素	穿孔素
細菌、病毒	天蠶素（英語：Cecropin）白喉毒素（英語：Diphtheria toxin） Dermaseptin（英語：Dermaseptin） Magainin（英語：Magainin）蜂毒肽（英語：Melittin）乳酸鏈球菌素（英語：Nisin）肺炎球菌溶血素（英語：Pneumolysin）